Detailed site distribution of melanoma and sunlight exposure: aetiological patterns from a Swiss series.

TitleDetailed site distribution of melanoma and sunlight exposure: aetiological patterns from a Swiss series.
Publication TypeJournal Article
Year of Publication2007
AuthorsBulliard, J-L, De Weck, D, Fisch, T, Bordoni, A, Levi, F
JournalAnn Oncol
Volume18
Issue4
Pagination789-94
Date Published2007 Apr
DOI10.1093/annonc/mdl490
ISSN0923-7534
KeywordsFemale, Humans, Male, Melanoma, Neoplasms, Radiation-Induced, Sex Characteristics, Skin Neoplasms, Sunlight
Abstract

BACKGROUND: The relation between detailed cutaneous distribution of melanoma and indicators of sun exposure patterns has scantily been explored in moderately sun-sensitive populations.

PATIENTS AND METHODS: The precise site of 1658 primary malignant melanoma, registered from 1995 to 2002, in Switzerland were retrieved and clinically validated. Relative melanoma density (RMD) was computed by the ratio of observed to expected number of melanoma allowing for body site surface areas, and further adjusted for site-specific melanocyte density.

RESULTS: Sites of highest risks were the face, shoulder and upper arm for both sexes, the back for men, and leg for women. Major features of this series were: (i) an unexpectedly high RMD for the face in women (5.6 versus 3.7 in men), (ii) the absence of a male predominance for melanoma on the ears and (iii) for the upper limbs, a steady gradient of increasing melanoma density with increasing proximity to the trunk, regardless of sex. Age and sex patterns of RMD parallelled general indicators of sun exposure and behaviour, except for the hand (RMD = 0.2).

CONCLUSION: RMD increased with (cumulative) site sun exposure, but a few notable exceptions support the impact of intermittent exposure in melanoma risk.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/17237475?dopt=Abstract

Alternate JournalAnn. Oncol.
Citation Key / SERVAL ID2474
PubMed ID17237475

                         

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