Association between inflammatory and obesity markers in a Swiss population-based sample (CoLaus Study).

TitleAssociation between inflammatory and obesity markers in a Swiss population-based sample (CoLaus Study).
Publication TypeJournal Article
Year of Publication2012
AuthorsMarques-Vidal, P, Bochud, M, Bastardot, F, Luscher, T, Ferrero, F, Gaspoz, J-M, Paccaud, F, Urwyler, A, von Kanel, R, Hock, C, Waeber, G, Preisig, M, Vollenweider, P
JournalObes Facts
Volume5
Issue5
Pagination734-44
Date Published2012
DOI10.1159/000345045
ISSN1662-4033
KeywordsAdipose Tissue, Adult, Aged, Biological Markers, Body Composition, Body Mass Index, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Inflammation, Interleukin-1beta, Interleukin-6, Male, Middle Aged, Obesity, Risk Factors, Sex Factors, Switzerland, Tumor Necrosis Factor-alpha, Waist Circumference
Abstract

OBJECTIVE: To assess the associations between obesity markers (BMI, waist circumference and %body fat) and inflammatory markers (interleukin-1β (IL-1β); interleukin-6 (IL-6); tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP)).

METHODS: Population sample of 2,884 men and 3,201 women aged 35-75 years. Associations were assessed using ridge regression adjusting for age, leisure-time physical activity, and smoking.

RESULTS: No differences were found in IL-1β levels between participants with increased obesity markers and healthy counterparts; multivariate regression showed %body fat to be negatively associated with IL-1β. Participants with high %body fat or abdominal obesity had higher IL-6 levels, but no independent association between IL-6 levels and obesity markers was found on multivariate regression. Participants with abdominal obesity had higher TNF-α levels, and positive associations were found between TNF-α levels and waist circumference in men and between TNF-α levels and BMI in women. Obese participants had higher hs-CRP levels, and these differences persisted after multivariate adjustment; similarly, positive associations were found between hs-CRP levels and all obesity markers studied.

CONCLUSION: Obesity markers are differentially associated with cytokine levels. %Body fat is negatively associated with IL-1β; BMI (in women) and waist circumference (in men) are associated with TNF-α; all obesity markers are positively associated with hs-CRP.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/23108472?dopt=Abstract

Alternate JournalObes Facts
Citation Key / SERVAL ID3338
PubMed ID23108472

                         

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