Use of GRADE for assessment of evidence about prognosis : rating confidence in estimates of event rates in broad categories of patients.

TitleUse of GRADE for assessment of evidence about prognosis : rating confidence in estimates of event rates in broad categories of patients.
Publication TypeJournal Article
Year of Publication2015
AuthorsIorio, A, Spencer, FA, Falavigna, M, Alba, C, Lang, E, Burnand, B, McGinn, T, Hayden, J, Williams, K, Shea, B, Wolff, R, Kujpers, T, Perel, P, Vandvik, PO, Glasziou, P, Schunemann, H, Guyatt, G
JournalBmj (clinical Research Ed.)
Volume350
Paginationh870
Date Published03/2015
DOI10.1136/bmj.h870
ISSN1756-1833 (Electronic)
KeywordsBias (Epidemiology), Diagnosis, Evidence-Based Medicine, Humans, Practice Guidelines as Topic, Prognosis, Publication Bias, Review Literature as Topic, Risk, Sensitivity and Specificity
Abstract

Main concepts : The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach defines quality of evidence as confidence in effect estimates; this conceptualization can readily be applied to bodies of evidence estimating the risk of future of events (that is, prognosis) in broadly defined populations In the field of prognosis, a body of observational evidence (including single arms of randomized controlled trials) begins as high quality evidence. The five domains GRADE considers in rating down confidence in estimates of treatment effect-that is, risk of bias, imprecision, inconsistency, indirectness, and publication bias-as well as the GRADE criteria for rating up quality, also apply to estimates of the risk of future of events from a body of prognostic studies Applying these concepts to systematic reviews of prognostic studies provides a ful approach to determine confidence in estimates of overall prognosis in broad populations.

Notes

Publication types: Journal ArticlePublication Status: epublish

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/25775931?dopt=Abstract

WOS ID (UT)

000351570500001

Alternate JournalBMJ
Citation Key / SERVAL IDserval:BIB_7CE153D7F89F
Peer reviewRefereed
PubMed ID25775931
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