Systematic evaluation of clinical predictors of aggressive ulcerative colitis

TitleSystematic evaluation of clinical predictors of aggressive ulcerative colitis
Publication TypeConference Paper
Year of Publication2015
AuthorsVavricka, S, Reinisch, F, Fournier, N, Pittet, V, Safroneeva, E, Scharl, M, Michetti, P, Rogler, G, Schoepfer, A
Conference NameJournal of Crohn's & Colitis; vol. 9 supl. 1
Date Published2015
Publisher10th Congress of ECCO-European Crohns & Colitis Organisation : Inflammatory bowel diseases. 18-21 February 2015, Barcelona, Spain
ISBN Number1873-9946
Accession NumberISI:000353811200245

Background: Studies evaluating risk factors associated with an "aggressive" disease course in ulcerative colitis (UC) are scarce. A recent definition of "aggressive" UC incorporated the followingcharacteristics: 1) high relapse rate, 2) need for surgery, 3) development of colorectal cancer, and 4) presence of extraintestinal manifestations (EIM). The following factors for an aggressive / disabling disease course in UC have been identified so far: age < 40 years at S140 Poster presentations UC diagnosis, pancolitis, concomitant primary sclerosing cholangitis, and deep ulcerations of the colonic mucosa. We aimed to evaluate risk factors for an "aggressive" disease course in UC patients.

Methods: Data from the Swiss IBD cohort study were analyzed. Patients were recruited from university centers (80%), regional hospitals (19%), and private practices (1%). We applied the following definition for "aggressive" UC: 1) patients ever treated with TNFantagonists or calcineurin inhibitors (tacrolimus / cyclosporine), and 2) need for (procto)-colectomy. Non-normal data are presented as median and interquartile range [IQR].


Poster Presentationt P129



Citation Key / SERVAL ID6058
Peer reviewRefereed
Thème IUMSP et mots clés: 


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