Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population.

TitleAssociations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population.
Publication TypeJournal Article
Year of Publication2016
AuthorsPruijm, M, Ponte, B, Ackermann, D, Paccaud, F, Guessous, I, Ehret, G, Pechère-Bertschi, A, Vogt, B, Mohaupt, MG, Martin, P-Y, Youhanna, SC, Nägele, N, Vollenweider, P, Waeber, G, Burnier, M, Devuyst, O, Bochud, M
JournalClinical Journal of the American Society of Nephrology
Volume11
Issue1
Pagination70-80
Date Published2016 Jan 7
DOI10.2215/CJN.04230415
ISSN1555-905X
ISBN Number1555-905X (Electronic)
Abstract

BACKGROUND AND OBJECTIVES: Allelic variants in UMOD, the gene coding for uromodulin, are associated with rare tubulointerstitial kidney disorders and risk of CKD and hypertension in the general population. The factors associated with uromodulin excretion in the normal population remain largely unknown, and were therefore explored in this study.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Urinary uromodulin excretion was measured using a validated ELISA in two population-based cohorts that included more than 6500 individuals. The Swiss Kidney Project on Genes in Hypertension study (SKIPOGH) included 817 adults (mean age±SD, 45±17 years) who underwent renal ultrasonography and performed a 24-hour urine collection. The Cohorte Lausannoise study included 5706 adults (mean age, 53±11 years) with fresh spot morning urine samples. We calculated eGFRs using the CKD-Epidemiology Collaboration formula and by 24-hour creatinine clearance.

RESULTS: In both studies, positive associations were found between uromodulin and urinary sodium, chloride, and potassium excretion and osmolality. In SKIPOGH, 24-hour uromodulin excretion (median, 41 [interquartile range, 29-57] mg/24 h) was positively associated with kidney length and volume and with creatinine excretion and urine volume. It was negatively associated with age and diabetes. Both spot uromodulin concentration and 24-hour uromodulin excretion were linearly and positively associated (multivariate analyses) with eGFR<90 ml/min per 1.73 m(2).

CONCLUSION: Age, creatinine excretion, diabetes, and urinary volume are independent clinical correlates of urinary uromodulin excretion. The associations of uromodulin excretion with markers of tubular functions and kidney dimensions suggest that it may reflect tubule activity in the general population.

Notes

Publication types: Journal ArticlePublication Status: ppublish

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/26683888?dopt=Abstract

WOS ID (UT)

000367766200013

Alternate JournalClin J Am Soc Nephrol
Citation Key / SERVAL ID6548
Peer reviewRefereed
PubMed ID26683888
PubMed Central IDPMC4702229

                         

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