Renal function in relation to low-level environmental lead exposure.

TitleRenal function in relation to low-level environmental lead exposure.
Publication TypeJournal Article
Year of Publication2019
AuthorsMujaj, B, Yang, W-Y, Zhang, Z-Y, Wei, F-F, Thijs, L, Verhamme, P, Staessen, JA
JournalNephrology, dialysis, transplantation
Date Published06/2019
KeywordseGFR, Environmental Exposure, Lead, Occupational Medicine, renal function

Background: Numerous studies suggested that occupational or environmental exposure to lead adversely affects renal function. However, most studies lost relevance because of the substantially lower current environmental lead exposure and all relied on serum creatinine to estimate glomerular filtration. We investigated the association of estimated glomerular filtration rate (eGFR), estimated from serum creatinine, cystatin C or both, with blood lead (BPb) using the baseline measurements of the ongoing Study for Promotion of Health in Recycling Lead (SPHERL; NCT02243904) in newly hired workers prior to significant occupational lead exposure.

Methods: Among 447 men (participation rate, 82.7%), we assessed the association of eGFR and the urinary albumin-to-creatinine ratio (ACR) with BPb across thirds of the BPb distribution using linear regression analysis. Fully adjusted models accounted for age, blood pressure, body mass index, the waist-to-hip ratio, smoking, the total-to-high-density-lipoprotein ratio, plasma glucose, serum γ-glutamyltransferase and antihypertensive drug treatment.

Results: Age averaged 28.7 (SD, 10.2) years (range, 19.1-31.8). Geometric mean BPb concentration was 4.34 μg/dL (5th-95th percentile interval, 0.9-14.8). In unadjusted and adjusted analyses, eGFR estimated from serum creatinine [mean (SD), 105.26 (15.2) mL/min/1.73 m2], serum cystatin C [mean (SD), 127.8 (13.8) mL/min/1.73 m2] or both [mean (SD), 111.9 (14.8) mL/min/1.73 m2] was not associated with BPb (P  ≥  0.36), whereas ACR [geometric mean, 4.32 mg/g (5th-95th percentile interval, 1.91-12.50)] was lower with higher BPb.

Conclusions: At the BPb levels observed in this study, there was no evidence for an association between renal function and lead exposure.

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First publication date (online)




Alternate JournalNephrol. Dial. Transplant.
Citation Key / SERVAL ID9067
Peer reviewRefereed
PubMed ID30165570


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