Childhood adversity: A gateway to multimorbidity in older age?

TitleChildhood adversity: A gateway to multimorbidity in older age?
Publication TypeJournal Article
Year of Publication2019
AuthorsHenchoz, Y, Seematter-Bagnoud, L, Nanchen, D, Büla, C, von Gunten, A, Demonet, J-F, Santos-Eggimann, B
JournalArchives of gerontology and geriatrics
Volume80
Pagination31-37
Date Published01/2019
DOI10.1016/j.archger.2018.10.003
ISSN1872-6976
KeywordsAged, Child, Cohort Studies, Epidemiology, Female, Health Behavior, Humans, Independent Living, Life-course, Male, Multimorbidity, Psychological/complications, Public Health, Quality of Life, Social Class, Stress
Abstract

BACKGROUND: Multimorbidity, or co-occurrence of several chronic diseases, has major consequences in terms of function, quality of life and mortality. Recent advances suggest that the aetiology of multimorbidity includes a life-long process. The purpose of this study was to determine the association between childhood adversity and multimorbidity in community-dwelling older adults, and to investigate variation in participants born immediately before, during and at the end of the Second World War.

METHODS: Participants were 4731 community-dwelling older adults who enrolled in the Lausanne cohort 65+ study (Switzerland) at age 65-70 years in 2004/2009/2014. A baseline questionnaire provided several indicators of childhood adversity including premature birth, food restrictions, child labour, family economic environment, serious illness/accident, and stressful life events. Multimorbidity at age 67-72 years was defined as ≥2 active chronic diseases at the 2-year follow-up questionnaire.

RESULTS: All childhood adversity indicators except premature birth were significantly associated with multimorbidity. Odds ratio (OR) ranged from 1.23 (P = 0.034) for poor family economic environment to 1.74 (P < 0.001) for stressful life events. In a multivariable model adjusted for socioeconomic status, health behaviours and stressful life events in adulthood (>16 years), a history of serious illness/accident (OR = 1.45; P < 0.001) and stressful life events (OR = 1.42; P = 0.001) in childhood remained significantly associated with multimorbidity. Comparisons between cohorts indicated substantial variations in the prevalence of childhood adversity indicators but similar associations with multimorbidity.

CONCLUSION: There was an independent association between childhood adversity and multimorbidity after age 65. This study encourages a comprehensive life-course perspective to better understand and potentially prevent multimorbidity.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/30336372?dopt=Abstract

First publication date (online)

10/2018

WOS ID (UT)

000450882400004

Alternate JournalArch Gerontol Geriatr
Citation Key / SERVAL ID9146
Peer reviewRefereed
PubMed ID30336372

                         

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