A correlated frailty model with long-term survivors for estimating the heritability of breast cancer.

TitreA correlated frailty model with long-term survivors for estimating the heritability of breast cancer.
Publication TypeJournal Article
Year of Publication2007
AuthorsLocatelli, I, Rosina, A, Lichtenstein, P, Yashin, AI
JournalStat Med
Volume26
Issue20
Pagination3722-34
Date Published2007 Sep 10
DOI10.1002/sim.2761
ISSN0277-6715
Mots-clésBreast Neoplasms, Disease Susceptibility, Diseases in Twins, Environmental Exposure, Female, Humans, Models, Statistical, Registries, Survivors, Sweden, Twin Studies as Topic
Abstract

The aim of this study is to investigate the role of genetics and environment in susceptibility to breast cancer (frailty). An interdisciplinary approach was adopted, combining a correlated frailty-mixture model with genetic equations, allowing for decomposition of the frailty variance into genetic and environmental components. In addition, the possibility that a fraction of the population under study is 'immune' to the disease is evaluated, and changes in heritability estimates introducing a fraction of non-susceptible individuals are determined. The methodology is applied to breast cancer data from the Swedish Twin Registry, including information about all female monozygotic and dizygotic twin pairs born in Sweden between 1886 and 1967. The inferential problem is solved in a Bayesian framework and the numerical work is carried out using Markov chain Monte Carlo (MCMC) methods.

Notes

SAPHIRID:59878 –- Old month value: Sept

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/17139701?dopt=Abstract

Alternate JournalStat Med
Citation Key / SERVAL ID2461
PubMed ID17139701

                         

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