The effect of thrombolysis on short-term improvement depends on initial stroke severity.

TitreThe effect of thrombolysis on short-term improvement depends on initial stroke severity.
Publication TypeJournal Article
Year of Publication2012
AuthorsNtaios, G, Faouzi, M, Michel, P
JournalJ Neurol
Date Published2012 Mar
Mots-clésAged, Aged, 80 and over, Analysis of Variance, Brain Ischemia, Female, Glucose, Humans, Male, Middle Aged, Prospective Studies, Retrospective Studies, Severity of Illness Index, Stroke, Thrombolytic Therapy, Time Factors, Treatment Outcome

A large number of parameters have been identified as predictors of early outcome in patients with acute ischemic stroke. In the present work we analyzed a wide range of demographic, metabolic, physiological, clinical, laboratory and neuroimaging parameters in a large population of consecutive patients with acute ischemic stroke with the aim of identifying independent predictors of the early clinical course. We used prospectively collected data from the Acute Stroke Registry and Analysis of Lausanne. All consecutive patients with ischemic stroke admitted to our stroke unit and/or intensive care unit between 1 January 2003 and 12 December 2008 within 24 h after last-well time were analyzed. Univariate and multivariate analyses were performed to identify significant associations with the National Institute of Health Stroke Scale (NIHSS) score at admission and 24 h later. We also sought any interactions between the identified predictors. Of the 1,730 consecutive patients with acute ischemic stroke who were included in the analysis, 260 (15.0%) were thrombolyzed (mostly intravenously) within the recommended time window. In multivariate analysis, the NIHSS score at 24 h after admission was associated with the NIHSS score at admission (β = 1, p

Alternate URL

Alternate JournalJ. Neurol.
Citation Key / SERVAL ID3100
PubMed ID21877207


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