Relation between high-sensitivity C-reactive protein and cardiovascular and renal markers in a middle-income country in the African region.

TitreRelation between high-sensitivity C-reactive protein and cardiovascular and renal markers in a middle-income country in the African region.
Publication TypeJournal Article
Year of Publication2012
AuthorsRossi, IAnne, Bochud, M, Viswanathan, B, Riesen, W, Bovet, P
JournalInt J Cardiol
Volume156
Issue2
Pagination203-8
Date Published2012 Apr 19
DOI10.1016/j.ijcard.2011.09.084
ISSN1874-1754
Mots-clésAdult, Biological Markers, C-Reactive Protein, Cardiovascular Diseases, Female, Humans, Income, Kidney Diseases, Male, Middle Aged, Population Surveillance, Risk Factors, Seychelles
Abstract

BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) is associated with several cardiovascular risk factors (CVRF) and with renal function markers. However, these associations have not been examined in populations in the African region. We analyzed the distribution of hs-CRP and the relationship with a broad set of CVRF, renal markers and carotid intima-media thickness (IMT), in the Seychelles (African region).

METHODS: We conducted a survey in the population aged 25-64 years (n=1255, participation rate: 80.2%). Analyses were restricted to persons of predominantly African descent (n=1011).

RESULTS: Mean and median hs-CRP serum concentrations (mg/l) were 3.1 (SD 7.6) and 1.4 (IQR 0.7-2.9) in men and 4.5 (SD 6.7) and 2.2 (IQR 1.0-5.4) in women (p

CONCLUSIONS: Serum concentration of hs-CRP was significantly associated with sex, several CVRF and selected renal function markers, which extends similar findings in Europe and in North America to a population in the African region. These findings can contribute to guide recommendations for the use of hs-CRP in clinical practice in the region.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/22018511?dopt=Abstract

Alternate JournalInt. J. Cardiol.
Citation Key / SERVAL ID3139
PubMed ID22018511

                         

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