Nutrient-based dietary patterns and the risk of head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium.

TitreNutrient-based dietary patterns and the risk of head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium.
Publication TypeJournal Article
Year of Publication2012
AuthorsEdefonti, V, Hashibe, M, Ambrogi, F, Parpinel, M, Bravi, F, Talamini, R, Levi, F, Yu, G, Morgenstern, H, Kelsey, K, McClean, M, Schantz, S, Zhang, Z, Chuang, S, Boffetta, P, La Vecchia, C, Decarli, A
JournalAnn Oncol
Volume23
Issue7
Pagination1869-80
Date Published2012 Jul
DOI10.1093/annonc/mdr548
ISSN1569-8041
Mots-clésCase-Control Studies, Diet, Food Habits, Humans, Laryngeal Neoplasms, Mouth Neoplasms, Odds Ratio, Pharyngeal Neoplasms, Risk Factors
Abstract

BACKGROUND: The association between dietary patterns and head and neck cancer has rarely been addressed.

PATIENTS AND METHODS: We used individual-level pooled data from five case-control studies (2452 cases and 5013 controls) participating in the International Head and Neck Cancer Epidemiology consortium. A posteriori dietary patterns were identified through a principal component factor analysis carried out on 24 nutrients derived from study-specific food-frequency questionnaires. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional logistic regression models on quintiles of factor scores.

RESULTS: We identified three major dietary patterns named 'animal products and cereals', 'antioxidant vitamins and fiber', and 'fats'. The 'antioxidant vitamins and fiber' pattern was inversely related to oral and pharyngeal cancer (OR=0.57, 95% CI 0.43-0.76 for the highest versus the lowest score quintile). The 'animal products and cereals' pattern was positively associated with laryngeal cancer (OR=1.54, 95% CI 1.12-2.11), whereas the 'fats' pattern was inversely associated with oral and pharyngeal cancer (OR=0.78, 95% CI 0.63-0.97) and positively associated with laryngeal cancer (OR=1.69, 95% CI 1.22-2.34).

CONCLUSIONS: These findings suggest that diets rich in animal products, cereals, and fats are positively related to laryngeal cancer, and those rich in fruit and vegetables inversely related to oral and pharyngeal cancer.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/22123733?dopt=Abstract

Alternate JournalAnn. Oncol.
Citation Key / SERVAL ID3154
PubMed ID22123733
PubMed Central IDPMC3387823
Grant ListCA100679 / CA / NCI NIH HHS / United States
CA78609 / CA / NCI NIH HHS / United States
P50CA90388 / CA / NCI NIH HHS / United States
R01CA51845 / CA / NCI NIH HHS / United States
R01DA11386 / DA / NIDA NIH HHS / United States
R03CA113157 / CA / NCI NIH HHS / United States
R03CA77954 / CA / NCI NIH HHS / United States
R21ES011667 / ES / NIEHS NIH HHS / United States
T32CA09142 / CA / NCI NIH HHS / United States
U01CA96134 / CA / NCI NIH HHS / United States

                         

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