Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations.

TitreSex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations.
Publication TypeJournal Article
Year of Publication2012
AuthorsRossi, IAnne, Bochud, M, Bovet, P, Paccaud, F, Waeber, G, Vollenweider, P, Taffé, P
JournalEur J Epidemiol
Volume27
Issue5
Pagination379-84
Date Published2012 May
DOI10.1007/s10654-012-9671-0
ISSN1573-7284
Mots-clésAdiposity, Adult, African Continental Ancestry Group, Biological Markers, Body Mass Index, C-Reactive Protein, European Continental Ancestry Group, Female, Health Surveys, Humans, Leptin, Male, Middle Aged, Models, Statistical, Multivariate Analysis, Regression Analysis, Sex Factors, Seychelles, Switzerland
Abstract

Elevated high-sensitivity C-reactive protein (hs-CRP) concentration is associated with an increased risk of cardiovascular disease but this association seems to be largely mediated via conventional cardiovascular risk factors. In particular, the association between hs-CRP and obesity has been extensively demonstrated and correlations are stronger in women than men. We used fractional polynomials--a method that allows flexible modeling of non linear relations--to investigate the dose/response mathematical relationship between hs-CRP and several indicators of adiposity in Caucasians (Switzerland) and Africans (Seychelles) surveyed in two population-based studies. This relationship was non-linear exhibiting a steeper slope for low levels of hs-CRP and a higher level in women. The observed sex difference in the relationship between hs-CRP and adiposity almost disappeared upon adjustment for leptin, suggesting that these sex differences might be partially mediated, by leptin. All these relationship were similar in Caucasians and Africans. This is the first report on a non-linear relation, stratified by gender, between hs-CRP and adiposity.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/22392590?dopt=Abstract

Alternate JournalEur. J. Epidemiol.
Citation Key / SERVAL ID3195
PubMed ID22392590

                         

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