Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study).

TitreAssociation between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study).
Publication TypeJournal Article
Year of Publication2013
AuthorsMarques-Vidal, P, Bastardot, F, von Kanel, R, Paccaud, F, Preisig, M, Waeber, G, Vollenweider, P
JournalClin Endocrinol (Oxf)
Volume78
Issue2
Pagination232-41
Date Published2013 Feb
DOI10.1111/j.1365-2265.2012.04384.x
ISSN1365-2265
Mots-clésAdult, Aged, Biological Markers, Cross-Sectional Studies, Cytokines, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Inflammation, Insulin Resistance, Male, Middle Aged
Abstract

OBJECTIVE: The associations between inflammation, diabetes and insulin resistance remain controversial. Hence, we assessed the associations between diabetes, insulin resistance (using HOMA-IR) and metabolic syndrome with the inflammatory markers high-sensitive C-reactive protein (hs-CRP), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α).

DESIGN: Cross-sectional study.

PARTICIPANTS: Two thousand eight hundred and eighty-four men and 3201 women, aged 35-75, participated in this study.

METHODS: C-reactive protein was assessed by immunoassay and cytokines by multiplexed flow cytometric assay. In a subgroup of 532 participants, an oral glucose tolerance test (OGTT) was performed to screen for impaired glucose tolerance (IGT).

RESULTS: IL-6, TNF-α and hs-CRP were significantly and positively correlated with fasting plasma glucose (FPG), insulin and HOMA-IR. Participants with diabetes had higher IL-6, TNF-α and hs-CRP levels than participants without diabetes; this difference persisted for hs-CRP after multivariate adjustment. Participants with metabolic syndrome had increased IL-6, TNF-α and hs-CRP levels; these differences persisted after multivariate adjustment. Participants in the highest quartile of HOMA-IR had increased IL-6, TNF-α and hs-CRP levels; these differences persisted for TNF-α and hs-CRP after multivariate adjustment. No association was found between IL-1β levels and all diabetes and insulin resistance markers studied. Finally, participants with IGT had higher hs-CRP levels than participants with a normal OGTT, but this difference disappeared after controlling for body mass index (BMI).

CONCLUSION: We found that subjects with diabetes, metabolic syndrome and increased insulin resistance had increased levels of IL6, TNF-α and hs-CRP, while no association was found with IL-1β. The increased inflammatory state of subjects with IGT is partially explained by increased BMI.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/22409372?dopt=Abstract

Alternate JournalClin. Endocrinol. (Oxf)
Citation Key / SERVAL ID3200
PubMed ID22409372
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