Gene-environment interactions of selected pharmacogenes in arterial hypertension.

TitreGene-environment interactions of selected pharmacogenes in arterial hypertension.
Publication TypeJournal Article
Year of Publication2012
AuthorsBochud, M, Guessous, I
JournalExpert Rev Clin Pharmacol
Volume5
Issue6
Pagination677-86
Date Published2012 Nov
DOI10.1586/ecp.12.58
ISSN1751-2441
Mots-clésAntihypertensive Agents, Blood Pressure, Gene-Environment Interaction, Humans, Hypertension, Life Style, Pharmacogenetics, Phenotype, Polymorphism, Genetic
Abstract

Hypertension affects approximately 1 billion people worldwide. Owing to population aging, hypertension-related cardiovascular burden is expected to rise in the near future. In addition to genetic variants influencing the blood pressure response to antihypertensive drugs, several genes encoding for drug-metabolizing or -transporting enzymes have been associated with blood pressure and/or hypertension in humans (e.g., ACE, CYP1A2, CYP3A5, ABCB1 and MTHFR) regardless of drug treatment. These genes are also involved in the metabolism and transport of endogenous substances and their effects may be modified by selected environmental factors, such as diet or lifestyle. However, little is currently known on the complex interplay between environmental factors, endogenous factors, genetic variants and drugs on blood pressure control. This review will discuss the respective role of population-based primary prevention and personalized medicine for arterial hypertension, taking a pharmacogenomics' perspective focusing on selected pharmacogenes.

Notes

Publication types: Journal ArticlePublication Status: ppublish

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/23234325?dopt=Abstract

Alternate JournalExpert Rev Clin Pharmacol
Citation Key / SERVAL ID3358
PubMed ID23234325

                         

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