Determinants and burden of chronic kidney disease in the population-based CoLaus study: a cross-sectional analysis.

TitreDeterminants and burden of chronic kidney disease in the population-based CoLaus study: a cross-sectional analysis.
Publication TypeJournal Article
Year of Publication2013
AuthorsPonte, B, Pruijm, M, Marques-Vidal, P, Martin, P-Y, Burnier, M, Paccaud, F, Waeber, G, Vollenweider, P, Bochud, M
JournalNephrol Dial Transplant
Volume28
Issue9
Pagination2329-39
Date Published2013 Sep
DOI10.1093/ndt/gft206
ISSN1460-2385
Mots-clésAdult, Aged, Albuminuria, Biomarkers, Cardiovascular Diseases, Creatinine, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Food Habits, Glomerular Filtration Rate, Humans, Hypertension, Kidney Function Tests, Male, Middle Aged, Prevalence, Prognosis, Renal Insufficiency, Chronic, Risk Factors, Switzerland
Abstract

BACKGROUND: Chronic kidney disease (CKD) represents an increasing health burden. We present the population-based prevalence of CKD and compare the CKD Epidemiology collaboration (CKD-EPI) and modification of diet in renal disease (MDRD) equations to estimate the glomerular filtration rate, using the revised CKD classification with three albuminuria classes. We also explore factors associated with CKD.

METHODS: The Swiss population-based, cross-sectional CoLaus study conducted in Lausanne (2003-2006) included 2810 men and 3111 women aged 35-75. CKD prevalence was assessed using CKD-EPI and MDRD equations and albuminuria estimated by the albumin-to-creatinine ratio in spot morning urine. Multivariate logistic regression was used to analyse determinants of CKD.

RESULTS: Prevalence [95% confidence interval (CI)] of all stages CKD was 10.0% (9.2-10.8%) with CKD-EPI and 13.8% (12.9-14.6%) with MDRD. Using the revised CKD classification, the prevalence of low-, medium-, high- and very high-risk groups was 90.0, 8.46, 1.18 and 0.35% with CKD-EPI, respectively. With MDRD, the corresponding values were 86.24, 11.86, 1.55 and 0.35%. Using the revised classification, CKD-EPI systematically reclassified people in a lower risk category than MDRD. Age and obesity were more strongly associated with CKD in men [odds ratio (95% CI): 2.23(1.95; 2.56) per 10 years and 3.05(2.08;4.47), respectively] than in women [1.46 (1.29; 1.65) and 1.78 (1.30;2.44), respectively]. Hypertension, type 2 diabetes, serum homocysteine and uric acid were positively independently associated with CKD in men and women.

CONCLUSIONS: One in 10 adults suffers from CKD in the population of Lausanne. CKD-EPI systematically reclassifies people in a lower CKD risk category than MDRD. Serum homocysteine and uric acid levels are associated with CKD independently of classical risk factors such as age, hypertension and diabetes.

Notes

Publication types: Journal ArticlePublication Status: ppublish

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/23825103?dopt=Abstract

Alternate JournalNephrol. Dial. Transplant.
Citation Key / SERVAL ID3448
PubMed ID23825103
                         

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