Associations of serum uric acid and SLC2A9 variant with depressive and anxiety disorders: a population-based study.

TitreAssociations of serum uric acid and SLC2A9 variant with depressive and anxiety disorders: a population-based study.
Publication TypeJournal Article
Year of Publication2013
AuthorsLyngdoh, T, Bochud, M, Glaus, J, Castelao, E, Waeber, G, Vollenweider, P, Preisig, M
JournalPLoS One
Volume8
Issue10
Paginatione76336
Date Published2013
DOI10.1371/journal.pone.0076336
ISSN1932-6203
Mots-clésAdult, Anxiety Disorders, Comorbidity, Cross-Sectional Studies, Depressive Disorder, Major, Female, Genetic Variation, Genotype, Glucose Transport Proteins, Facilitative, Humans, Male, Middle Aged, Population Surveillance, Risk Factors, Sex Factors, Uric Acid
Abstract

BACKGROUND: Limited information exists regarding the association between serum uric acid (SUA) and psychiatric disorders. We explored the relationship between SUA and subtypes of major depressive disorder (MDD) and specific anxiety disorders. Additionally, we examined the association of SLC2A9 rs6855911 variant with anxiety disorders.

METHODS: We conducted a cross-sectional analysis on 3,716 individuals aged 35-66 years previously selected for the population-based CoLaus survey and who agreed to undergo further psychiatric evaluation. SUA was measured using uricase-PAP method. The French translation of the semi-structured Diagnostic Interview for Genetic Studies was used to establish lifetime and current diagnoses of depression and anxiety disorders according to the DSM-IV criteria.

RESULTS: Men reported significantly higher levels of SUA compared to women (357±74 µmol/L vs. 263±64 µmol/L). The prevalence of lifetime and current MDD was 44% and 18% respectively while the corresponding estimates for any anxiety disorders were 18% and 10% respectively. A quadratic hockey-stick shaped curve explained the relationship between SUA and social phobia better than a linear trend. However, with regards to the other specific anxiety disorders and other subtypes of MDD, there was no consistent pattern of association. Further analyses using SLC2A9 rs6855911 variant, known to be strongly associated with SUA, supported the quadratic relationship observed between SUA phenotype and social phobia.

CONCLUSIONS: A quadratic relationship between SUA and social phobia was observed consistent with a protective effect of moderately elevated SUA on social phobia, which disappears at higher concentrations. Further studies are needed to confirm our observations.

Notes

Publication types: Journal Article Publication Status: epublish

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/24204615?dopt=Abstract

Alternate JournalPLoS ONE
Citation Key / SERVAL ID3507
PubMed ID24204615
PubMed Central IDPMC3812204
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