Age-specific incidence of all neoplasms after colorectal cancer.

TitreAge-specific incidence of all neoplasms after colorectal cancer.
Publication TypeJournal Article
Year of Publication2014
AuthorsLevi, F, Randimbison, L, Blanc-Moya, R, La Vecchia, C
JournalAnnals of Epidemiology
Volume24
Issue10
Pagination785-788
Date Published10/2014
DOI10.1016/j.annepidem.2014.07.005
ISSN1047-2797 (linking)
ISBN Number1873-2585 (Electronic)
Mots-clésCancer registry, Colorectal cancer, Incidence, Multiple malignancies
Abstract

PURPOSE: Patients diagnosed with a specific neoplasm tend to have a subsequent excess risk of the same neoplasm. The age incidence of a second neoplasm at the same site is approximately constant with age, and consequently the relative risk is greater at younger age. It is unclear whether such a line of reasoning can be extended from a specific neoplasm to the incidence of all neoplasms in subjects diagnosed with a defined neoplasm.

METHODS: We considered the age-specific incidence of all non-hormone-related epithelial neoplasms after a first primary colorectal cancer (n = 9542) in the Vaud Cancer Registry data set.

RESULTS: In subjects with a previous colorectal cancer, the incidence rate of all other epithelial non-hormone-related cancers was stable around 800 per 100,000 between age 30 and 60 years, and rose only about twofold to reach 1685 at age 70 to 79 years and 1826 per 100,000 at age 80 years or older. After excluding synchronous cancers, the rise was only about 1.5-fold, that is, from about 700 to 1000. In the general population, the incidence rate of all epithelial non-hormone-related cancers was 29 per 100,000 at age 30 to 39 years, and rose 30-fold to 883 per 100,000 at age 70 to 79 years. Excluding colorectal cancers, the rise of all non-hormone-related cancers was from 360 per 100,000 at age 40 to 49 years to 940 at age 70 to 79 years after colorectal cancer, and from 90 to 636 per 100,000 in the general population (i.e., 2.6- vs. 7.1-fold).

CONCLUSIONS: The rise of incidence with age of all epithelial non-hormone-related second cancers after colorectal cancer is much smaller than in the general population. This can possibly be related to the occurrence of a single mutational event in a population of susceptible individuals, although alternative models are plausible within the complexity of the process of carcinogenesis.

Notes

IUMSP2014/10

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/25169681?dopt=Abstract

First publication date (online)

07/2014

WOS ID (UT)

000342329100013

Alternate JournalAnn Epidemiol
Citation Key / SERVAL ID3610
Peer reviewRefereed
PubMed ID25169681
Thème IUMSP et mots clés: 
                         

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