Leptin and smoking cessation: secondary analyses of a randomized controlled trial assessing physical activity as an aid for smoking cessation.

TitreLeptin and smoking cessation: secondary analyses of a randomized controlled trial assessing physical activity as an aid for smoking cessation.
Publication TypeJournal Article
Year of Publication2014
AuthorsGonseth-Nusslé, S, Locatelli, I, Bize, R, Nusslé, S, Clair, C, Pralong, F, Cornuz, J
JournalBMC Public Health
Volume14
Pagination911
Date Published09/2014
DOI10.1186/1471-2458-14-911
ISSN1471-2458
Mots-clésAdult, Biomarkers, Body Weight, Exercise, Female, Humans, Leptin, Male, Research Design, Smoking Cessation, Weight Gain
Abstract

BACKGROUND: Smokers have a lower body weight compared to non-smokers. Smoking cessation is associated with weight gain in most cases. A hormonal mechanism of action might be implicated in weight variations related to smoking, and leptin might be implicated. We made secondary analyses of an RCT, with a hypothesis-free exploratory approach to study the dynamic of leptin following smoking cessation.

METHODS: We measured serum leptin levels among 271 sedentary smokers willing to quit who participated in a randomized controlled trial assessing a 9-week moderate-intensity physical activity intervention as an aid for smoking cessation. We adjusted leptin for body fat levels. We performed linear regressions to test for an association between leptin levels and the study group over time.

RESULTS: One year after smoking cessation, the mean serum leptin change was +3.23 mg/l (SD 4.89) in the control group and +1.25 mg/l (SD 4.86) in the intervention group (p of the difference < 0.05). When adjusted for body fat levels, leptin was higher in the control group than in the intervention group (p of the difference < 0.01). The mean weight gain was +2.91 (SD 6.66) Kg in the intervention and +3.33 (SD 4.47) Kg in the control groups, respectively (p not significant).

CONCLUSIONS: Serum leptin levels significantly increased after smoking cessation, in spite of substantial weight gain. The leptin dynamic might be different in chronic tobacco users who quit smoking, and physical activity might impact the dynamic of leptin in such a situation. Clinical trial registration number: NCT00521391.

Notes

Publication types: Journal ArticlePublication Status: epublish

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/25187423?dopt=Abstract

WOS ID (UT)

000341651600001

Alternate JournalBMC Public Health
Citation Key / SERVAL ID3611
Peer reviewRefereed
PubMed ID25187423
PubMed Central IDPMC4165916
Thème IUMSP et mots clés: 

                         

IUMSP | www.iumsp.ch
Institut universitaire de médecine sociale et préventive
Route de la Corniche 10, 1010 Lausanne - Switzerland
+41 21 314 72 72 | dess.info@unisante.ch

Go to top