Effect of embryo culture media on birthweight and length in singleton term infants after IVF-ICSI.

TitreEffect of embryo culture media on birthweight and length in singleton term infants after IVF-ICSI.
Publication TypeJournal Article
Year of Publication2014
AuthorsWunder, D, Ballabeni, P, Roth-Kleiner, M, Primi, M-P, Senn, A, Chanson, A, Germond, M, Leyvraz, C
JournalSwiss Med Wkly
Date Published2014
ISBN Number1424-3997 (Electronic)

QUESTIONS UNDER STUDY: To investigate if two distinct, commercially available embryo culture media have a different effect on birthweight and length of singleton term infants conceived after IVF-ICSI.

METHODS: University hospital based cohort study. Between 1 January 2000 and 31 December 2004, patients conceiving through IVF-ICSI at the University Hospital, Lausanne have been allocated to two distinct embryo culture media. Only term singleton pregnancies were analysed (n = 525). Data analysis was performed according to two commercially available culture media: Vitrolife (n = 352) versus Cook (n = 173). Analysis was performed through linear regression adjusted for confounders. Media were considered equivalent if the 95% confidence interval lay between -150 g/+150 g.

RESULTS: Length, gestational age and distribution of birthweight percentiles did not differ between groups (for both genders). Analysis of the whole cohort, adjusted for a subset of confounders, resulted in a statistically not different mean birthweight between the two groups (Vitrolife +37 g vs Cook, 95%CI: -46 g to 119 g) suggesting equivalence. Adjustment for an enlarged number of confounders in a subsample of patients (n = 258) also revealed no relevant mean birthweight difference of +71 g (95%CI: -45 g to 187 g) in favour of Vitrolife; however, lacking power to prove equivalence.

CONCLUSIONS: Our data suggest that significant differences in birthweight due to these two distinct, commercially available embryo culture media are unlikely.


Publication types: Journal ArticlePublication Status: epublish

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Alternate JournalSwiss Med Wkly
Citation Key / SERVAL ID3623
PubMed ID25296194
Thème IUMSP et mots clés: 


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