Changes in the vascular reactivity of the isolated tail arteries of spontaneous and renovascular hypertensive rats to endogenous and exogenous noradrenaline.

TitreChanges in the vascular reactivity of the isolated tail arteries of spontaneous and renovascular hypertensive rats to endogenous and exogenous noradrenaline.
Publication TypeJournal Article
Year of Publication1987
AuthorsFouda, AK, Marazzi, A, Boillat, N, Sonnay, M, Guillain, H, Atkinson, J
JournalBlood Vessels
Volume24
Issue1-2
Pagination63-75
Date Published1987
ISSN0303-6847
Mots-clésAnimals, Arteries, Blood Pressure, Electric Stimulation, Heart Rate, Hypertension, Hypertension, Renovascular, In Vitro Techniques, Norepinephrine, Potassium, Rats, Rats, Inbred SHR, Rats, Inbred WKY, Tail, Vasoconstriction
Abstract

We have investigated the changes in the responses to noradrenaline of isolated tail arteries of spontaneously hypertensive (SHR) and renovascular hypertensive rats (Wistar-Kyoto: two-kidney, one-clip model, WKY:2K1C) compared with normotensive (Wistar-Kyoto, WKY) rats. Renovascular hypertension was induced by 4 weeks' unilateral renal artery clipping. Arteries were vasoconstricted with exogenous noradrenaline, electrical field stimulation or high potassium. The effects of the latter two stimuli were abolished by reserpine and so were presumably dependent on the presence of endogenous noradrenaline. In the SHR the maximal vasoconstriction produced by all three stimuli was greater than in WKY. Dose-response curves were steeper and there was no change in threshold. Vascular mass was greater. We interpret these results as showing an increase in vascular reactivity in the SHR caused by structural adaptation. The WKY:2K1C responses to noradrenaline could also be explained in terms of structural adaptation but there was no increase in vascular mass. Sensitivity to potassium and electrical stimulation was decreased, suggesting a defect in vascular neurotransmission. This was supported by the observations of a decreased arterial noradrenaline content and of decreased sensitivity to cocaine.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/3567366?dopt=Abstract

Alternate JournalBlood Vessels
Citation Key / SERVAL ID3665
PubMed ID3567366

                         

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