Neurofibromatosis of von Recklinghausen: a quantitative study of the epidermal keratinocyte and melanocyte populations.

TitreNeurofibromatosis of von Recklinghausen: a quantitative study of the epidermal keratinocyte and melanocyte populations.
Publication TypeJournal Article
Year of Publication1984
AuthorsFrenk, E, Marazzi, A
JournalJ Invest Dermatol
Volume83
Issue1
Pagination23-5
Date Published1984 Jul
ISSN0022-202X
Mots-clésAdult, Aged, Biopsy, Cell Count, Epidermis, Humans, Keratins, Melanocytes, Middle Aged, Neurofibromatosis 1
Abstract

The numerical keratinocyte to melanocyte relation was studied in café au lait spots and adjacent normally pigmented skin of 9 patients with classical neurofibromatosis. Compared to normal skin of healthy individuals, the keratinocyte:melanocyte ratio distributions obtained in neurofibromatosis indicated a shift to lower values in the biopsies of café au lait spots and normally pigmented skin. These results are evidence in favor of an impaired tissue organization of the epidermis in neurofibromatosis with regard to the keratinocyte-melanocyte interrelation.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/6203987?dopt=Abstract

Alternate JournalJ. Invest. Dermatol.
Citation Key / SERVAL ID3687
PubMed ID6203987
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