[Interlaboratory variation in the prenatal screening test for neural tube closing defects].

Titre[Interlaboratory variation in the prenatal screening test for neural tube closing defects].
Publication TypeJournal Article
Year of Publication1984
AuthorsBraoudakis, G, Marguerat, P, Marazzi, A, Gutzwiller, F
JournalSoz Praventivmed
Volume29
Issue4-5
Pagination207-8
Date Published1984
ISSN0303-8408
Mots-clésalpha-Fetoproteins, Female, Humans, Laboratories, Neural Tube Defects, Pregnancy, Prenatal Diagnosis, Switzerland
Abstract

Early detection of neural-tude defects is possible by determining Alpha-fetoprotein (AFP) in maternal serum. 16'685 pregnant women were observed. Three methods for the determination of the "normal" range are compared. The first one, already used in similar studies, makes use of a constant multiple of the median. The other two ones make use of robust estimates of location and scale. Their comparison shows the interest of the robust methods to reduce the interlaboratory variability.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/6207680?dopt=Abstract

Alternate JournalSoz Praventivmed
Citation Key / SERVAL ID3688
PubMed ID6207680
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