Extraintestinal manifestations in inflammatory bowel disease: frequency and associated risk factors in the nationwide Swiss IBD cohort study (SIBDCS)

TitreExtraintestinal manifestations in inflammatory bowel disease: frequency and associated risk factors in the nationwide Swiss IBD cohort study (SIBDCS)
Publication TypeConference Paper
Year of Publication2010
AuthorsVavricka, SR, Brun, L, Ballabeni, P, Pittet, V, Manz, M, M. Vavricka, P, Michetti, P, Beglinger, C, Fried, M, Rogler, G, Schoepfer, AM
Conference NameDigestive Disease Week 2010
Conference LocationNew Orleans, Louisiana, United-States, May 2-5, 2010
ISBN Number0016-5085 (print)
Accession Numberserval:BIB_A71E28446B83
Mots-clésCohort Studies, Inflammatory Bowel Diseases/complications, Inflammatory Bowel Diseases/epidemiology, Risk Factors, Switzerland
Abstract

Background: Data on the frequency of extraintestinal
manifestations (EIM) in Crohnʼs disease (CD) and ulcerative
colitis (UC) are scarce. Goal: to evaluate prevalences, forms of
EIM and risk factors in a large nationwide IBD cohort.
Methods: Data from validated physician enrolment
questionnaires of the adult Swiss IBD cohort were analyzed.
Logistic regression models were used to identify EIM risk
factors.
Results: 950 patients were included, 580 (61%) with
CD (mean age 43yrs) and 370 (39%) with UC (mean age
49yrs), of these, 249 (43%) of CD and 113 (31%) of UC patients
had one to 5 EIM. The following EIM were found: arthritis (CD
33%, UC 21%), aphthous stomatitis (CD 10%, UC 4%), uveitis
(CD 6%, UC 4%), erythema nodosum (CD 6%, UC 3%),
ankylosing spondylitis (CD 6%, UC 2%), psoriasis (CD 2%, UC
1%), pyoderma gangrenosum (CD and UC each 2%), primary
sclerosing cholangitis (CD 1%, UC 4%). Logistic regression in
CD identified the following items as risk factors for ongoing EIM:
active disease (OR 1.95, 95% CI 1.17-3.23, P=0.01), positive
IBD family history (OR 1.77, 95% CI 1.07-2.92, P=0.025). No
risk factors were identified in UC patients.
Conclusions: EIM
are a frequent problem in CD and UC patients. Active disease
and positive IBD family history are associated with ongoing EIM
in CD patients. Identification of EIM prevalence and associated
risk factors may result in increased awareness for this problem
and thereby facilitate their diagnosis and management.

Notes

oai:serval.unil.ch:BIB_A71E28446B83

DOI10.1016/S0016-5085(10)60927-4
Citation Key / SERVAL ID4540
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