Characteristics of non-responders to self-reported questionnaires in a large inflammatory bowel disease cohort study.

TitreCharacteristics of non-responders to self-reported questionnaires in a large inflammatory bowel disease cohort study.
Publication TypeJournal Article
Year of Publication2015
AuthorsMultone, E, Vader, J-P, Mottet, C, Schoepfer, A, Fournier, N, Burnand, B, Michetti, P, Pittet, V
JournalScandinavian Journal of Gastroenterology
Date Published2015
ISSN1502-7708 (Electronic)
Mots-clésAdult, Age Factors, Anxiety, Colitis, Ulcerative, Crohn Disease, Depression, Female, Humans, Longitudinal Studies, Lost to Follow-Up, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Quality of Life, Risk Factors, Selection Bias, Self Report, Surveys and Questionnaires, Switzerland

BACKGROUND: A major threat to the validity of longitudinal cohort studies is non-response to follow-up, which can lead to erroneous conclusions. The objective of this study was to evaluate the profile of non-responders to self-reported questionnaires in the Swiss inflammatory bowel disease (IBD) Cohort.

METHODS: We used data from adult patients enrolled between November 2006 and June 2011. Responders versus non-responders were compared according to socio-demographic, clinical and psychosocial characteristics. Odds ratio for non-response to initial patient questionnaire (IPQ) compared to 1-year follow-up questionnaire (FPQ) were calculated.

RESULTS: A total of 1943 patients received IPQ, in which 331 (17%) did not respond. Factors inversely associated with non-response to IPQ were age >50 and female gender (OR = 0.37; p < 0.001 respectively OR = 0.63; p = 0.003) among Crohn's disease (CD) patients, and disease duration >16 years (OR = 0.48; p = 0.025) among patients with ulcerative colitis (UC). FPQ was sent to 1586 patients who had completed the IPQ; 263 (17%) did not respond. Risk factors of non-response to FPQ were mild depression (OR = 2.17; p = 0.003) for CD, and mild anxiety (OR = 1.83; p = 0.024) for UC. Factors inversely associated with non-response to FPQ were: age >30 years, colonic only disease location, higher education and higher IBD-related quality of life for CD, and age >50 years or having a positive social support for UC.

CONCLUSIONS: Characteristics of non-responders differed between UC and CD. The risk of non-response to repetitive solicitations (longitudinal versus transversal study) seemed to decrease with age. Assessing non-respondents' characteristics is important to document potential bias in longitudinal studies.


Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish

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Alternate JournalScand. J. Gastroenterol.
Citation Key / SERVAL ID6007
Peer reviewRefereed
PubMed ID25921677


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