Chronological Order of Appearance of Extraintestinal Manifestations Relative to the Time of IBD Diagnosis in the Swiss Inflammatory Bowel Disease Cohort.

TitreChronological Order of Appearance of Extraintestinal Manifestations Relative to the Time of IBD Diagnosis in the Swiss Inflammatory Bowel Disease Cohort.
Publication TypeJournal Article
Year of Publication2015
AuthorsVavricka, SR, Rogler, G, Gantenbein, C, Spoerri, M, Vavricka, MPrinz, Navarini, AA, French, LE, Safroneeva, E, Fournier, N, Straumann, A, Froehlich, F, Fried, M, Michetti, P, Seibold, F, Lakatos, PL, Peyrin-Biroulet, L, Schoepfer, AM
JournalInflammatory Bowel Diseases
Volume21
Issue8
Pagination1794-1800
Date Published08/2015
DOI10.1097/MIB.0000000000000429
ISSN1536-4844
ISBN Number1536-4844 (Electronic)
Mots-clésAdolescent, Adult, Aged, Aged, 80 and over, Arthritis, Cohort Studies, Erythema Nodosum, Female, Follow-Up Studies, Humans, Inflammatory Bowel Diseases, Male, Middle Aged, Prognosis, Pyoderma Gangrenosum, Spondylitis, Ankylosing, Stomatitis, Aphthous, Switzerland, Time Factors, Young Adult
Abstract

BACKGROUND: Data evaluating the chronological order of appearance of extraintestinal manifestations (EIMs) relative to the time of inflammatory bowel disease (IBD) diagnosis is currently lacking. We aimed to assess the type, frequency, and chronological order of appearance of EIMs in patients with IBD.

METHODS: Data from the Swiss Inflammatory Bowel Disease Cohort Study were analyzed.

RESULTS: The data on 1249 patients were analyzed (49.8% female, median age: 40 [interquartile range, 30-51 yr], 735 [58.8%] with Crohn's disease, 483 [38.7%] with ulcerative colitis, and 31 [2.5%] with indeterminate colitis). A total of 366 patients presented with EIMs (29.3%). Of those, 63.4% presented with 1, 26.5% with 2, 4.9% with 3, 2.5% with 4, and 2.7% with 5 EIMs during their lifetime. Patients presented with the following diseases as first EIMs: peripheral arthritis 70.0%, aphthous stomatitis 21.6%, axial arthropathy/ankylosing spondylitis 16.4%, uveitis 13.7%, erythema nodosum 12.6%, primary sclerosing cholangitis 6.6%, pyoderma gangrenosum 4.9%, and psoriasis 2.7%. In 25.8% of cases, patients presented with their first EIM before IBD was diagnosed (median time 5 mo before IBD diagnosis: range, 0-25 mo), and in 74.2% of cases, the first EIM manifested itself after IBD diagnosis (median: 92 mo; range, 29-183 mo).

CONCLUSIONS: In one quarter of patients with IBD, EIMs appeared before the time of IBD diagnosis. Occurrence of EIMs should prompt physicians to look for potential underlying IBD.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/26020601?dopt=Abstract

WOS ID (UT)

000359190700009

Alternate JournalInflamm. Bowel Dis.
Citation Key / SERVAL ID6015
Peer reviewRefereed
PubMed ID26020601

                         

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