Association between obesity and glomerular hyperfiltration: the confounding effect of smoking and sodium and protein intakes.

TitreAssociation between obesity and glomerular hyperfiltration: the confounding effect of smoking and sodium and protein intakes.
Publication TypeJournal Article
Year of Publication2016
AuthorsOgna, A, Ogna, VForni, Bochud, M, Guessous, I, Paccaud, F, Burnier, M, Wuerzner, G
JournalEur J Nutr
Volume55
Issue3
Pagination1089-97
Date Published2016 Apr
DOI10.1007/s00394-015-0923-0
ISSN1436-6215
Abstract

PURPOSE: Glomerular hyperfiltration has been suggested as a possible mechanism linking obesity and chronic kidney disease (CKD), independently of classical risk factors. We explored the association of overweight and obesity with glomerular hyperfiltration in a large sample of the Swiss adult population, accounting for several confounders including dietary factors.

METHODS: Data from a 2010 to 2012 cross-sectional population-based survey in Switzerland were used. Creatinine clearance (CrCl) was determined from 24-h urine collection; CrCl > 140 ml/min was used to define glomerular hyperfiltration. Participants were categorized into lean (

RESULTS: A total of 1339 participants were included in the analysis [median (IQR) age 49.4 (34.3-63.5) years, 48.9 % men]. The prevalences of overweight and obesity were 32.2 and 14.2 %, respectively. Median CrCl was 102[84-121] ml/min in lean, 110 [87-136] ml/min in overweight and 124 [97-150] ml/min in obese participants (p

CONCLUSIONS: BMI categories and glomerular hyperfiltration are positively associated, independently of other known CKD risk factors and dietary confounders, suggesting that glomerular hyperfiltration may represent an early renal phenotype in obesity. Our observations confirm the significant association of glomerular hyperfiltration with sodium and protein intakes and identify sodium intake as an important modifying factor of the association between hyperfiltration and obesity.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/25971845?dopt=Abstract

Alternate JournalEur J Nutr
Citation Key / SERVAL ID6019
PubMed ID25971845

                         

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