Compliance with preoperative oral nutritional supplements in patients at nutritional risk--only a question of will?

TitreCompliance with preoperative oral nutritional supplements in patients at nutritional risk--only a question of will?
Publication TypeJournal Article
Year of Publication2015
AuthorsGrass, F, Bertrand, PC, Schäfer, M, Ballabeni, P, Cerantola, Y, Demartines, N, Hübner, M
JournalEuropean Journal of Clinical Nutrition
Date Published04/2015
Mots-clésAdministration, Oral, Aged, Aged, 80 and over, Appetite, C-Reactive Protein, Dietary Supplements, Digestive System Surgical Procedures, Female, Food Habits, Hemoglobins, Humans, Life Style, Logistic Models, Male, Middle Aged, Multivariate Analysis, Nutrition Assessment, Nutritional Status, Patient Compliance, Preoperative Care, Prospective Studies, Randomized Controlled Trials as Topic, Retrospective Studies, Risk Factors, Treatment Outcome

BACKGROUND/OBJECTIVES: Preoperative nutrition has been shown to reduce morbidity after major gastrointestinal (GI) surgery in selected patients at risk. In a randomized trial performed recently (NCT00512213), almost half of the patients, however, did not consume the recommended dose of nutritional intervention. The present study aimed to identify the risk factors for noncompliance.

SUBJECTS/METHODS: Demographic (n = 5) and nutritional (n = 21) parameters for this retrospective analysis were obtained from a prospectively maintained database. The outcome of interest was compliance with the allocated intervention (ingestion of ⩾ 11/15 preoperative oral nutritional supplement units). Uni- and multivariate analyses of potential risk factors for noncompliance were performed.

RESULTS: The final analysis included 141 patients with complete data sets for the purpose of the study. Fifty-nine patients (42%) were considered noncompliant. Univariate analysis identified low C-reactive protein levels (P = 0.015), decreased recent food intake (P = 0.032) and, as a trend, low hemoglobin (P = 0.065) and low pre-albumin (P = 0.056) levels as risk factors for decreased compliance. However, none of them was retained as an independent risk factor after multivariate analysis. Interestingly, 17 potential explanatory parameters, such as upper GI cancer, weight loss, reduced appetite or co-morbidities, did not show any significant correlation with reduced intake of nutritional supplements.

CONCLUSIONS: Reduced compliance with preoperative nutritional interventions remains a major issue because the expected benefit depends on the actual intake. Seemingly, obvious reasons could not be retained as valid explanations. Compliance seems thus to be primarily a question of will and information; the importance of nutritional supplementation needs to be emphasized by specific patients' education.


Publication types: Journal Article Publication Status: ppublish

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Alternate JournalEur J Clin Nutr
Citation Key / SERVAL ID6034
Peer reviewRefereed
PubMed ID25604779
Thème IUMSP et mots clés: 


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