P298 Comparison between clinical and patient-reported symptoms among Crohn's disease and ulcerative colitis patients

TitreP298 Comparison between clinical and patient-reported symptoms among Crohn's disease and ulcerative colitis patients
Publication TypeConference Paper
Year of Publication2017
AuthorsPittet, V, Maillard, MH, Rogler, G, Michetti, P
Conference NameCongress of ECCO: European of Crohn's and Colitis Organisation
Date Published01/2017
PublisherJournal of Crohn's and Colitis ; Oxford University Press (OUP)
Conference Location12th Congress of ECCO was held on February 15-18, 2017 at the CCIB in Barcelona.
Mots-clésCrohns disease, Gastroenterology, ulcerative colitis

Background: There is no symptom-based patient-reported outcomes (PRO) measurement available in IBD. Disease scores contain a mixture of PRO and physician's observations and have shown serious limitations in clinical trials. Comparison between healthcare professionals (HCP) and patient (P) reports on scores' items is a first step toward disease scores refinement. In our IBD cohort study, we were able to collect P and HCP-reported symptoms independently. We assessed the agreement between both measures, and tested the correlation between the general well-being item (GWB) and two health-related quality of life (HRQoL) measures.

Methods: Between 2012 and 2015, we collected CDAI and MTWAI items 1) during follow-up medical visits, 2) through P self-reported follow-up questionnaire, except lab values. We compared items independently reported by HCP and P, stratified by diagnostic and Δt HCP-P reports. We calculated the Cohen's kappa (κ) statistic for agreement. A quadratic weight was applied for more severely serious disagreements. For EIM & complications, we computed a pooled κ based on the average between observed and expected probability of agreement over sub-items. A pooled κ was computed to summarize agreement over all examined variables. We also collected SF-36 and IBDQ scores. Pearson correlation coefficients r were calculated between both scores and GWB reports of HCP and P.

Results: 2427 reports could be evaluated (Δt: 537<1 month, 390 1–2, 1500 2–6), referring to 1385 patients (52% females, 58% CD).


Poster presentations: Clinical: Diagnosis and outcome (2017)

Citation Key / SERVAL ID7537
Peer reviewNon-Refereed


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