SQC: Secure Quality Control for Meta-Analysis of Genome-Wide Association Studies.

TitreSQC: Secure Quality Control for Meta-Analysis of Genome-Wide Association Studies.
Publication TypeJournal Article
Year of Publication2017
AuthorsHuang, Z, Lin, H, Fellay, J, Kutalik, Z, Hubaux, J-P
JournalBioinformatics
Date Published04/2017
DOI10.1093/bioinformatics/btx193
ISSN1367-4811
Abstract

Motivation: Due to the limited power of small-scale genome-wide association studies (GWAS), researchers tend to collaborate and establish a larger consortium in order to perform large-scale GWAS. Genome-wide association meta-analysis (GWAMA) is a statistical tool that aims to synthesize results from multiple independent studies to increase the statistical power and reduce false-positive findings of GWAS. However, it has been demonstrated that the aggregate data of individual studies are subject to inference attacks, hence privacy concerns arise when researchers share study data in GWAMA.

Results: In this article, we propose a secure quality control (SQC) protocol, which enables checking the quality of data in a privacy-preserving way without revealing sensitive information to a potential adversary. SQC employs state-of-the-art cryptographic and statistical techniques for privacy protection. We implement the solution in a meta-analysis pipeline with real data to demonstrate the efficiency and scalability on commodity machines. The distributed execution of SQC on a cluster of 128 cores for one million genetic variants takes less than one hour, which is a modest cost considering the 10-month time span usually observed for the completion of the QC procedure that includes timing of logistics.

Availability and Implementation: SQC is implemented in Java and is publicly available at https://github.com/acs6610987/secureqc.

Contact: jean- .

Supplementary information: Supplementary data are available at Bioinformatics online.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/28379351?dopt=Abstract

Alternate JournalBioinformatics
Citation Key / SERVAL ID7661
Peer reviewRefereed
PubMed ID28379351
                         

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