Risk Factors for the Development of Fistulae and Stenoses in Crohn Disease Patients in the Swiss Inflammatory Bowel Disease Cohort

TitreRisk Factors for the Development of Fistulae and Stenoses in Crohn Disease Patients in the Swiss Inflammatory Bowel Disease Cohort
Publication TypeJournal Article
Year of Publication2017
AuthorsZeitz, J, Fournier, N, Labenz, C, Biedermann, L, Frei, P, Misselwitz, B, Scharl, S, Vavricka, SR, Sulz, MC, Fried, M, Rogler, G, Scharl, M
Corporate Authorsfor the Swiss Inflammatory Bowel Disease Cohort Study Group
JournalInflammatory Intestinal Diseases
Volume1
Issue4
Pagination172 - 181
Date Published04/2017
URLhttps://www.karger.com/?doi=10.1159/000458144https://www.karger.com/Article/Pdf/458144
DOI10.1159/000458144
ISSN2296-9403
Mots-clésCrohn Disease, Fistula, Inflammatory bowel disease, Risk Factors, Stenosis ·
Abstract

Background: Fistulae and stenoses represent frequent and severe complications in patients with Crohn disease (CD). Our study aimed to identify risk factors for fistula and stenosis formation in CD patients.

Summary: We retrieved data of 1,600 CD patients from the nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). The risk for fistulae and stenoses in relation to gender, age at diagnosis, smoking status at diagnosis, and ileal involvement at diagnosis were analyzed. In the multivariate analysis, female gender showed a lower risk for developing perianal and any fistula (risk ratio [RR] 0.721, 95% confidence interval [CI] 0.582-0.893, p = 0.003 and RR 0.717, 95% CI 0.580-0.888, p = 0.002, respectively), and older age at diagnosis showed a lower risk for developing perianal fistula (RR 0.661, 95% CI 0.439-0.995, p = 0.047). Furthermore, ileal involvement was associated with a lower risk for perianal fistula (RR 0.713, 95% CI 0.561-0.906, p = 0.006), a lower risk for any fistula (RR 0.709, 95% CI 0.558-0.901, p = 0.005), and a higher risk for stenosis (RR 2.170, 95% CI 1.728-2.725, p < 0.001).

Key Messages: In the nationwide SIBDCS, younger age at diagnosis and male gender were risk factors for developing perianal and nonperianal fistulae. Additionally, ileal involvement was revealed to be a potent risk factor (RR 2.170) for developing a stenosis.

Short TitleInflamm Intest Dis
Citation Key / SERVAL ID7993
Peer reviewNon-Refereed
                         

IUMSP | www.iumsp.ch
Institut universitaire de médecine sociale et préventive
Route de la Corniche 10, 1010 Lausanne - Switzerland
+41 21 314 72 72 | iumsp@chuv.ch

Go to top