Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

TitreNovel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
Publication TypeJournal Article
Year of Publication2017
AuthorsWain, LV, Vaez, A, Jansen, R, Joehanes, R, van der Most, PJ, A Erzurumluoglu, M, O'Reilly, PF, Cabrera, CP, Warren, HR, Rose, LM, Verwoert, GC, Hottenga, J-J, Strawbridge, RJ, Esko, T, Arking, DE, Hwang, S-J, Guo, X, Kutalik, Z, Trompet, S, Shrine, N, Teumer, A, Ried, JS, Bis, JC, Smith, AV, Amin, N, Nolte, IM, Lyytikainen, L-P, Mahajan, A, Wareham, NJ, Hofer, E, Joshi, PK, Kristiansson, K, Traglia, M, Havulinna, AS, Goel, A, Nalls, MA, Sõber, S, Vuckovic, D, Luan, J'an, M, FDel Greco, Ayers, KL, Marrugat, J, Ruggiero, D, Lopez, LM, Niiranen, T, Enroth, S, Jackson, AU, Nelson, CP, Huffman, JE, Zhang, W, Marten, J, Gandin, I, Harris, SE, Zemunik, T, Lu, Y, Evangelou, E, Shah, N, de Borst, MH, Mangino, M, Prins, BP, Campbell, A, Li-Gao, R, Chauhan, G, Oldmeadow, C, Abecasis, G, Abedi, M, Barbieri, CM, Barnes, MR, Batini, C, Beilby, J, Blake, T, Boehnke, M, Bottinger, EP, Braund, PS, Brown, M, Brumat, M, Campbell, H, Chambers, JC, Cocca, M, Collins, F, Connell, J, Cordell, HJ, Damman, JJ, Davies, G, de Geus, EJ, de Mutsert, R, Deelen, J, Demirkale, Y, Doney, ASF, Dörr, M, Farrall, M, Ferreira, T, Frånberg, M, Gao, H, Giedraitis, V, Gieger, C, Giulianini, F, Gow, AJ, Hamsten, A, Harris, TB, Hofman, A, Holliday, EG, Hui, J, Jarvelin, M-R, Johansson, A, Johnson, AD, Jousilahti, P, Jula, A, Kahonen, M, Kathiresan, S, Khaw, K-T, Kolcic, I, Koskinen, S, Langenberg, C, Larson, M, Launer, LJ, Lehne, B, Liewald, DCM, Lin, L, Lind, L, Mach, F, Mamasoula, C, Menni, C, Mifsud, B, Milaneschi, Y, Morgan, A, Morris, AD, Morrison, AC, Munson, PJ, Nandakumar, P, Nguyen, QTri, Nutile, T, Oldehinkel, AJ, Oostra, BA, Org, E, Padmanabhan, S, Palotie, A, Pare, G, Pattie, A, Penninx, BWJH, Poulter, N, Pramstaller, PP, Raitakari, OT, Ren, M, Rice, K, Ridker, PM, Riese, H, Ripatti, S, Robino, A, Rotter, JI, Rudan, I, Saba, Y, Pierre, ASaint, Sala, CF, Sarin, A-P, Schmidt, R, Scott, R, Seelen, MA, Shields, DC, Siscovick, D, Sorice, R, Stanton, A, Stott, DJ, Sundström, J, Swertz, M, Taylor, KD, Thom, S, Tzoulaki, I, Tzourio, C, Uitterlinden, AG, Völker, U, Vollenweider, P, Wild, S, Willemsen, G, Wright, AF, Yao, J, Thériault, S, Conen, D, Attia, J, Sever, P, Debette, S, Mook-Kanamori, DO, Zeggini, E, Spector, TD, van der Harst, P, Palmer, CNA, Vergnaud, A-C, Loos, RJF, Polasek, O, Starr, JM, Girotto, G, Hayward, C, Kooner, JS, Lindgren, CM, Vitart, V, Samani, NJ, Tuomilehto, J, Gyllensten, U, Knekt, P, Deary, IJ, Ciullo, M, Elosua, R, Keavney, BD, Hicks, AA, Scott, RA, Gasparini, P, Laan, M, Liu, Y, Watkins, H, Hartman, CA, Salomaa, V, Toniolo, D, Perola, M, Wilson, JF, Schmidt, H, Zhao, JHua, Lehtimaki, T, van Duijn, CM, Gudnason, V, Psaty, BM, Peters, A, Rettig, R, James, A, J Jukema, W, Strachan, DP, Palmas, W, Metspalu, A, Ingelsson, E, Boomsma, DI, Franco, OH, Bochud, M, Newton-Cheh, C, Munroe, PB, Elliott, P, Chasman, DI, Chakravarti, A, Knight, J, Morris, AP, Levy, D, Tobin, MD, Snieder, H, Caulfield, MJ, Ehret, GB
JournalHypertension
Volume70
Issue3
PaginationE4-E19
Date Published09/2017
DOI10.1161/HYPERTENSIONAHA.117.09438
ISSN1524-4563
Mots-clésBlood Pressure, cardiovascular risk, complex traits, eSNP, GWAS, Hypertension
Abstract

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/28739976?dopt=Abstract

First publication date (online)

07/2017

WOS ID (UT)

000407241500001

Alternate JournalHypertension
Citation Key / SERVAL ID8146
Peer reviewRefereed
PubMed ID28739976

                         

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