Correlation study between osteoporosis and hematopoiesis in the context of adjuvant chemotherapy for breast cancer.

TitreCorrelation study between osteoporosis and hematopoiesis in the context of adjuvant chemotherapy for breast cancer.
Publication TypeJournal Article
Year of Publication2017
AuthorsSchyrr, F, Wolfer, A, Pasquier, J, Nicoulaz, A-L, Lamy, O, Naveiras, O
JournalAnnals of hematology
Date Published11/2017
DOI10.1007/s00277-017-3184-6
ISSN1432-0584
Mots-clésAnemia, Bone marrow adipocytes, Bone marrow microenvironment, Breast cancer, Chemotherapy, Febrile neutropenia, Graded toxicity of chemotherapy, Hematopoiesis, Neutrophil, Osteoblast, Osteoporosis, Platelet, Stress hematopoiesis, T-score, TBS, Trabecular bone score
Abstract

This retrospective study attempts to establish if a correlation exists between osteoporosis and hematopoiesis before and after adjuvant chemotherapy in the context of non-metastatic breast cancer. Osteoporosis is interpreted both as a direct marker of osteoblastic decline and as an indirect marker of increased bone marrow adiposity within the hematopoietic microenvironment. Patients from the "Centre du Sein" at CHUV (Centre Hospitalier Universitaire Vaudois) undergoing adjuvant chemotherapy were included in this study. Evolution of blood counts was studied in correlation with the osteoporosis status. Toxicity of chemotherapy was coded according to published probability of febrile neutropenia. One hundred forty-three women were included: mean age 52.1 ± 12.5 years, mean BMI (body mass index) 24.4 ± 4.1. BMD (bone mineral density) scored osteoporotic in 32% and osteopenic in 45%. Prior to chemotherapy, BMD was positively correlated with neutrophil (p < 0.001) and thrombocyte (p = 0.01) count; TBS (trabecular bone score) was not correlated with blood count. After the first cycle of chemotherapy, an increase of one point in TBS correlated with a decrease of 57% on the time to reach leucocyte nadir (p = 0.004). There was a positive correlation between BMD and risk of infection (p < 0.001). Our data demonstrates an association between osteoporosis and lower blood counts in a younger cohort than previously published, extending it for the first time to neutrophil counts in females. Our results suggest that the healthier the bone, the earlier the lowest leucocyte count value, prompting further research on this area.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/29170810?dopt=Abstract

Alternate JournalAnn. Hematol.
Citation Key / SERVAL ID8411
Peer reviewRefereed
PubMed ID29170810
Grant ListPP00P3_144857 / / SNSF Professorship / United States
"Centre du Sein", CHUV/CINO and CHUV/DO / / Centre Hospitalier Universitaire Vaudois / United States
                         

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