Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation.

TitreSocial adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation.
Publication TypeJournal Article
Year of Publication2017
AuthorsFiorito, G, Polidoro, S, Dugué, P-A, Kivimaki, M, Ponzi, E, Matullo, G, Guarrera, S, Assumma, MB, Georgiadis, P, Kyrtopoulos, SA, Krogh, V, Palli, D, Panico, S, Sacerdote, C, Tumino, R, Chadeau-Hyam, M, Stringhini, S, Severi, G, Hodge, AM, Giles, GG, Marioni, R, Linnér, RKarlsson, O'Halloran, AM, Kenny, RA, Layte, R, Baglietto, L, Robinson, O, McCrory, C, Milne, RL, Vineis, P
JournalScientific reports
Volume7
Issue1
Pagination16266
Date Published11/2017
DOI10.1038/s41598-017-16391-5
ISSN2045-2322
Abstract

Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social environment. Socioeconomic adversity is associated with accelerated epigenetic aging, implicating biomolecular mechanisms that may link SES to age-related diseases and longevity.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/29176660?dopt=Abstract

Alternate JournalSci Rep
Citation Key / SERVAL ID8413
Peer reviewRefereed
PubMed ID29176660
PubMed Central IDPMC5701128
                         

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