Age at disease onset of inflammatory bowel disease is associated with later extraintestinal manifestations and complications.

TitreAge at disease onset of inflammatory bowel disease is associated with later extraintestinal manifestations and complications.
Publication TypeJournal Article
Year of Publication2018
AuthorsHerzog, D, Fournier, N, Buehr, P, Rueger, V, Koller, R, Heyland, K, Nydegger, A, Spalinger, J, Schibli, S, Petit, L-M, Braegger, CP
Corporate AuthorsGroup, SIBDCohort
JournalEuropean journal of gastroenterology & hepatology
Volume30
Issue6
Pagination598-607
Date Published06/2018
DOI10.1097/MEG.0000000000001072
ISSN1473-5687
Mots-clésAdolescent, Adult, Age of Onset, Anemia/epidemiology, Ankylosing/epidemiology, Aphthous/epidemiology, Arthralgia/epidemiology, Bone Diseases, Child, Cholangitis, Colitis, Crohn Disease/diagnosis, Crohn Disease/epidemiology, Crohn Disease/therapy, Disease Progression, Female, Humans, Male, Metabolic/epidemiology, Prevalence, Prognosis, Prospective Studies, Registries, Retrospective Studies, Risk Factors, Sclerosing/epidemiology, Severity of Illness Index, Spondylitis, Stomatitis, Switzerland/epidemiology, Time Factors, Ulcerative/diagnosis, Ulcerative/epidemiology, Ulcerative/therapy
Abstract

INTRODUCTION: A small but increasing number of patients with inflammatory bowel disease are diagnosed during childhood or adolescence, and disease distribution and severity at onset vary according to the age at diagnosis. Clinical factors present at the time of diagnosis can be predictive of the disease course.

AIM: The aim of this study was to characterize disease behavior and the cumulative complications and extraintestinal manifestations 10 years after the diagnosis and to assess their association with age at diagnosis.

PATIENTS AND METHODS: Data of patients participating with the Swiss IBD cohort study registry, a disease duration of 10 years and a complete data set were analyzed. The outcome was defined as the cumulative change of disease behavior, the occurrence of extra-intestinal manifestations or complications, and the necessity for medical or surgical interventions.

RESULTS: A total of 481 patients with Crohn's disease (CD) and 386 patients with ulcerative colitis (UC), grouped according to disease onset before 10, 17, 40, or after 40 years of age, were analyzed. Despite differences in sex, initial disease location, and smoking habits, at 10 years after the diagnosis, no difference was found regarding disease behavior in CD or regarding progression of disease extension in UC. Similarly, no age-of-onset-dependent cumulative need for medical or surgical therapies was found. However, higher rates of anemia and lower rates of arthralgia and osteopenia were found in both pediatric-onset CD and UC, and a tendency toward higher rates of stomatitis in pediatric-onset CD, and of primary sclerosing cholangitis and ankylosing spondylitis in pediatric-onset UC.

CONCLUSION: After 10 years of disease evolution, age at disease onset is not anymore associated with disease behavior but only with a small difference in the occurrence of specific extraintestinal manifestations and complications.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/29360691?dopt=Abstract

First publication date (online)

01/2018

WOS ID (UT)

000431298900002

Alternate JournalEur J Gastroenterol Hepatol
Citation Key / SERVAL IDBIB_84EBD62C3D4D
Peer reviewRefereed
PubMed ID29360691
                         

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