Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients.

TitreLow serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients.
Publication TypeJournal Article
Year of Publication2018
AuthorsGreuter, T, Franc, Y, Kaelin, M, Schoepfer, AM, Schreiner, P, Zeitz, J, Scharl, M, Misselwitz, B, Straumann, A, Vavricka, SR, Rogler, G, von Kanel, R, Biedermann, L
JournalTherapeutic advances in gastroenterology
Volume11
Pagination1756283X18757715
Date Published02/2018
DOI10.1177/1756283X18757715
ISSN1756-283X
Mots-clésAnxiety, ATG16L1, Crohn’s disease, Depression, disease course, single nucleotide polymorphism, Zinc
Abstract

Background: Zinc deficiency (ZD) in Crohn's disease (CD) is considered a frequent finding and may exacerbate CD activity. ZD is associated with depression in non-CD patients. We aimed to assess the prevalence of ZD in CD patients in clinical remission, its association with mood disturbances and to analyze a potential impact on future disease course.

Methods: Zinc levels from CD patients in clinical remission at baseline and an uncomplicated disease course within the next 3 years (= 47) were compared with those from patients developing complications (= 50). Baseline symptoms of depression and anxiety were measured with the Hospital Anxiety and Depression scale.

Results: Mean zinc level in the 97 patients (40.4 ± 15.7 years, 44.3% males) was 18.0 ± 4.7 μmol/l. While no ZD (<11 μmol/l) was observed, we found low zinc levels (<15.1 μmol/l) in 28 patients (28.9%). Males had higher zinc levels compared with females (19.4 ± 5.716.8 ± 3.3,= 0.006). Patients with low zinc levels more often reported depression symptoms compared with patients with higher levels (27.39.4%,= 0.047). In a multivariate analysis, zinc levels were an independent negative predictor for depression symptoms [odds ratio (OR) 0.727, 95% confidence interval (CI) 0.532-0.993,= 0.045]. Zinc levels of patients with a complicated disease course were not different from those of patients without (17.7 ± 4.318.3 ± 5.1, n.s.). Baseline zinc levels did not predict disease outcome regardless of ATG16L1 genotype.

Conclusion: Low-normal zinc levels were an independent predictor for the presence of depression symptoms in CD patients. Zinc levels at baseline did not predict a complicated disease course, neither in CD patients overall, nor ATG16L1carriers.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/29487628?dopt=Abstract

WOS ID (UT)

000443078400001

Alternate JournalTherap Adv Gastroenterol
Citation Key / SERVAL ID8667
Peer reviewRefereed
PubMed ID29487628
PubMed Central IDPMC5821298

                         

IUMSP | www.iumsp.ch
Institut universitaire de médecine sociale et préventive
Route de la Corniche 10, 1010 Lausanne - Switzerland
+41 21 314 72 72 | dess.info@unisante.ch

Go to top