Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study.

TitreBurden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study.
Publication TypeJournal Article
Year of Publication2018
AuthorsChatzis, O, Darbre, S, Pasquier, J, Meylan, P, Manuel, O, Aubert, JDavid, Beck-Popovic, M, Masouridi-Levrat, S, Ansari, M, Kaiser, L, Posfay-Barbe, KM, Asner, SA
JournalBMC infectious diseases
Date Published2018 03 06

BACKGROUND: Respiratory syncytial virus (RSV) is associated with significant mortality rates amongst hematopoietic stem cell transplant (HSCT) recipients, with less known about other immunocompromised patients.

METHODS: Ten-year retrospective cohort study of immunocompromised patients presenting with RSV disease documented at University Hospitals of Lausanne and Geneva. Severe RSV-related outcomes referred to RSV documented respiratory conditions requiring hospital admission, presenting as lower respiratory tract infection (LRTI) or pneumonia. We used multivariable logistic regression to assess clinical and laboratory correlates of severe RSV disease.

RESULTS: From 239 RSV-positive immunocompromised in and out-patients 175 were adults and 64 children of whom 111 (47.8%) presented with LRTI, which resulted in a 38% (89/239) admission rate to hospital. While immunocompromised children were more likely to be admitted to hospital compared to adults (75% vs 62.9%, p = 0.090), inpatients admitted to the intensive care unit (17/19) or those who died (11/11) were mainly adults. From multivariable analyses, adults with solid tumors (OR 5.2; 95% CI: 1.4-20.9 P = 0.015) or those requiring chronic immunosuppressive treatments mainly for rheumatologic conditions (OR 4.1; 95% CI: 1.1-16.0; P = 0.034) were significantly more likely to be admitted to hospital compared to hematopoietic stem cell (HSCT) recipients. Bacterial co-infection was significantly and consistently associated with viral LRTI and pneumonia.

CONCLUSIONS: From our findings, RSV-related disease results in a significant burden among adults requiring chronic immunosuppressive treatments for rheumatological conditions and those with solid tumors. As such, systematic screening for respiratory viruses, should be extended to other immunocompromised populations than HSCT recipients.

Alternate URL




Alternate JournalBMC Infect. Dis.
Citation Key / SERVAL ID8714
Peer reviewRefereed
PubMed ID29510663
PubMed Central IDPMC5838875


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