Multicentre observational screening survey for the detection of CTEPH following PE.

TitreMulticentre observational screening survey for the detection of CTEPH following PE.
Publication TypeJournal Article
Year of Publication2018
AuthorsCoquoz, N, Weilenmann, D, Stolz, D, Popov, V, Azzola, A, Fellrath, J-M, Stricker, H, Pagnamenta, A, Ott, S, Ulrich, S, Györik, S, Pasquier, J, Aubert, J-D
JournalThe European respiratory journal
Paginationpii: 1702505
Date Published04/2018
Mots-clésAged, Chronic Disease, Female, Humans, Hypertension, Incidence, Male, Mass Screening, Middle Aged, Prospective Studies, Pulmonary Embolism/complications, Pulmonary/epidemiology, Registries, Risk Factors, Sensitivity and Specificity, Surveys and Questionnaires, Switzerland/epidemiology, Thromboembolism/complications

Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe complication of pulmonary embolism (PE). Its incidence following PE is debated. An active screening for CTEPH in patients with acute PE is yet to be recommended.This prospective, multicentre, observational study (INPUT on PE; ISRCTN61417303) included patients with acute PE from 11 centres in Switzerland from March 2009 to November 2016. Screening for possible CTEPH was performed at 6, 12 and 24 months using a step-wise algorithm that included a dyspnoea phone-based survey, transthoracic echocardiography, right heart catheterisation and radiologic confirmation of CTEPH.Of 1699 patients with PE, 508 patients were assessed for CTEPH screening over 2 years. The CTEPH incidence following PE was 3.7 per 1000 patient-years, with a two-year cumulative incidence of 0.79%. The Swiss pulmonary hypertension registry consulted in December 2016 did not report additional CTEPH cases in these patients. The survey yielded 100% sensitivity and 81.6% specificity. The second step echocardiography in newly dyspnoeic patients showed a negative predictive value of 100%.CTEPH is a rare but treatable disease. A simple and sensitive way for CTEPH screening in patients with acute PE is recommended.

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First publication date (online)




Alternate JournalEur. Respir. J.
Citation Key / SERVAL ID8716
Peer reviewRefereed
PubMed ID29563171


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