Precision Medicine - Crossing the Bridge to Public Health and Clinical Relevance

- Colloque IUMSP
Prof. Richard Cooper

Professor & Chair
Public Health Sciences
Loyola University Medical School, Chicago, Illinois, USA

Résumé : The advent of genomic technology has led to major advances in biomedical science, particularly in relation to monogenic disorders, tumor biology and the genetic architecture of complex traits. It is argued that genomics will continue to revolutionize all of biomedicine– now called Precision Medicine (PM). For common diseases, however, where the greatest impact of PM is expected, prediction of disease risk and treatment outcomes has been weak. Lack of success results from several factors: a) the genome is not the domain of interest when the intent is to discover disease causation, b) use of genomic data in clinical research violates several key logical assumptions of epidemiology and clinical trials c), the “reductionist mystique” has permitted genomics to engage in exaggeration, which clouds judgment regarding the empirical outcome. A great deal is at stake given the enormous financial and human resources diverted to genomics in recent years and the vast investment in clinical services built around PM.

Date et heure
Mardi, 22 Mai, 2018 - 11:00
Salle Delachaux (étage 01), Institut universitaire de médecine sociale et préventive, Bâtiment Biopôle 2, route de la Corniche 10, 1010 Lausanne

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