The IARC Perspective on Colorectal Cancer Screening.

TitreThe IARC Perspective on Colorectal Cancer Screening.
Publication TypeJournal Article
Year of Publication2018
AuthorsLauby-Secretan, B, Vilahur, N, Bianchini, F, Guha, N, Straif, K
Secondary AuthorsBulliard, J-L
Corporate AuthorsInternational Agency for Research on Cancer Handbook Working Group
JournalN Engl J Med
Date Published2018 05 03
Mots-clésColonography, Computed Tomographic, Colonoscopy, Colorectal Neoplasms, Comparative Effectiveness Research, Early Detection of Cancer, Humans, Mass Screening, Occult Blood, Risk Factors

Colorectal cancer, which is the third most common cancer in men and the second most common in women, represents almost 10% of the annual global cancer incidence. Incidence rates of colorectal cancer show a strong positive gradient with an increasing level of economic development. Even so, the net 5-year rate of survival decreases with lower levels of income, with rates reaching 60% in high-income countries but falling to 30% or less in low-income countries.
Established risk factors for colorectal cancer include consumption of processed meats, consumption of alcoholic beverages, tobacco smoking, and excess body fat, whereas consumption of dietary fiber and dairy products and increased levels of physical activity decrease the risk. In addition, certain subgroups of the population are at increased risk owing to genetic predisposition (e.g., the Lynch syndrome), a family or personal history of colorectal neoplasia, or medical conditions (e.g., inflammatory bowel disease) that have been associated with colorectal cancer.

Alternate URL



Alternate JournalN. Engl. J. Med.
Citation Key / SERVAL ID8876
Peer reviewRefereed
PubMed ID29580179


Institut universitaire de médecine sociale et préventive
Route de la Corniche 10, 1010 Lausanne - Switzerland
+41 21 314 72 72 |

Go to top