CD73 expression and clinical significance in human metastatic melanoma.

TitreCD73 expression and clinical significance in human metastatic melanoma.
Publication TypeJournal Article
Year of Publication2018
AuthorsMonteiro, I, Vigano, S, Faouzi, M, Treilleux, I, Michielin, O, Ménétrier-Caux, C, Caux, C, Romero, P, De Leval, L
JournalOncotarget
Volume9
Issue42
Pagination26659-26669
Date Published06/2018
DOI10.18632/oncotarget.25426
ISSN1949-2553
Mots-clésCD73, ecto-5'-nucleotidase, Immunohistochemistry, Melanoma, Prognosis
Abstract

Background: CD73 is an ectoenzyme involved in the production of adenosine. It exerts immunosuppressive and protumoral roles and has emerged as a potential immuno-oncology target.

Results: CD73 expression was detected in TC in 54% of melanoma metastases, involving < 50% TC in the majority of the cases, with variable intensity. CD73 expression was significantly associated with a lower Breslow's depth of the primary lesion and was more frequent in patients having received prior non-surgical therapies. In an adjusted analysis, CD73 expression in TC (H-score > 37.5 or intensity > 1) significantly correlated to decreased overall survival (OS) from biopsy. Of the samples containing TIMC, 35% presented CD73+ TIMC. Highly infiltrated tumors were more likely to contain CD73+ TIMC. CD73 expression in TIMC (percentage ≥1%) significantly correlated with improved OS from biopsy.

Conclusions: Immunohistochemistry detected CD73 expression in more than half of metastatic melanomas. While CD73 expression in TC significantly correlated with decreased OS, CD73 expression in TIMC significantly associated with improved OS. These results encourage the study of anti-CD73 therapies for metastatic melanoma patients.

Methods: CD73 expression was assessed by immunohistochemistry in metastatic melanomas from 114 patients. Immunostainings were evaluated in tumor cells (TC) (percentage, intensity (1-3) and H-score) and in tumor-infiltrating mononuclear cells (TIMC) (percentage).

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/29928476?dopt=Abstract

Alternate JournalOncotarget
Citation Key / SERVAL ID8955
Peer reviewRefereed
PubMed ID29928476
PubMed Central IDPMC6003551

                         

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