Pretherapeutic Motor Thalamus Resting-State Functional Connectivity with Visual Areas Predicts Tremor Arrest After Thalamotomy for Essential Tremor: Tracing the Cerebello-thalamo-visuo-motor Network.

TitrePretherapeutic Motor Thalamus Resting-State Functional Connectivity with Visual Areas Predicts Tremor Arrest After Thalamotomy for Essential Tremor: Tracing the Cerebello-thalamo-visuo-motor Network.
Publication TypeJournal Article
Year of Publication2018
AuthorsTuleasca, C, Najdenovska, E, Régis, J, Witjas, T, Girard, N, Champoudry, J, Faouzi, M, Thiran, J-P, Cuadra, MBach, Levivier, M, Van De Ville, D
JournalWorld neurosurgery
Volume117
Paginatione438-e449
Date Published09/2018
DOI10.1016/j.wneu.2018.06.049
ISSN1878-8769
Mots-clés80 and over, Activities of Daily Living, Aged, Cerebellum/physiology, essential tremor, Essential Tremor/radiotherapy, Female, fMRI, Humans, Magnetic Resonance Imaging/methods, Male, Middle Aged, Motor Cortex/physiology, Neuroimaging/methods, Postoperative Care, Preoperative Care, Radiosurgery, Radiosurgery/methods, Resting-state, Seed-based approach, thalamotomy, Treatment Outcome, Ventral Thalamic Nuclei/physiopathology, Ventral Thalamic Nuclei/surgery, Ventrointermediate nucleus, Visual Cortex/physiology
Abstract

BACKGROUND: Essential tremor (ET) is a common movement disorder. Resting-state functional magnetic resonance imaging is a noninvasive neuroimaging method acquired in absence of task.

OBJECTIVE: Our study aimed to correlate pretherapeutic ventrolateral thalamus functional connectivity (FC) with clinical results 1 year after stereotactic radiosurgical thalamotomy (SRS-T) for drug-resistant ET. Data from 12 healthy control individuals were additionally included.

METHODS: Resting state was acquired for 17 consecutive (right-handed) patients, before and 1 year after left unilateral SRS-T. Standard tremor scores were evaluated pretherapeutically and 1 year after SRS-T. Tremor network was investigated using region of interest, left ventrolateral ventral (VLV) cluster, obtained from pretherapeutic diffusion magnetic resonance imaging. Seed-based FC was obtained as correlations between the time courses of the VLV and that of every other voxel. The seed-connectivity maps were obtained pretherapeutically and correlated across all patients with clinical outcome 1 year after SRS-T. One-year magnetic resonance signature volume was always located inside VLV and did not correlate with reported seed-FC measures (P > 0.05).

RESULTS: We report statistically significant correlations between pretherapeutic VLV FC with clinical outcome for 1) right visual association area (Brodmann area, BA19) predicting 1 year activities of daily living decrease (P = 0.02); 2) left fusiform gyrus (BA37) predicting 1 year head tremor score improvement (P = 0.04); and 3) posterior cingulate (left BA23, P = 0.009), lateral temporal cortex (right BA21, P = 0.02) predicting time to tremor arrest.

CONCLUSIONS: Our results suggest that pretherapeutic resting-state seed-FC of left VLV predicts tremor arrest after SRS-T for ET. Visual areas are identified as the main regions in this correlation.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/29920392?dopt=Abstract

First publication date (online)

06/2018

WOS ID (UT)

000442440400053

Alternate JournalWorld Neurosurg
Citation Key / SERVAL ID8980
Peer reviewRefereed
PubMed ID29920392

                         

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