Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

TitreGene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
Publication TypeJournal Article
Year of Publication2018
AuthorsLee, JJ, Wedow, R, Okbay, A, Kong, E, Maghzian, O, Zacher, M, Nguyen-Viet, TAnh, Bowers, P, Sidorenko, J, Linnér, RKarlsson, Fontana, MAlan, Kundu, T, Lee, C, Li, H, Li, R, Royer, R, Timshel, PN, Walters, RK, Willoughby, EA, Yengo, L, Alver, M, Bao, Y, Clark, DW, Day, FR, Furlotte, NA, Joshi, PK, Kemper, KE, Kleinman, A, Langenberg, C, Mägi, R, Trampush, JW, Verma, SSetia, Wu, Y, Lam, M, Zhao, JHua, Zheng, Z, Boardman, JD, Campbell, H, Freese, J, Harris, KMullan, Hayward, C, Herd, P, Kumari, M, Lencz, T, Luan, J'an, Malhotra, AK, Metspalu, A, Milani, L, Ong, KK, Perry, JRB, Porteous, DJ, Ritchie, MD, Smart, MC, Smith, BH, Tung, JY, Wareham, NJ, Wilson, JF, Beauchamp, JP, Conley, DC, Esko, T, Lehrer, SF, Magnusson, PKE, Oskarsson, S, Pers, TH, Robinson, MR, Thom, K, Watson, C, Chabris, CF, Meyer, MN, Laibson, DI, Yang, J, Johannesson, M, Koellinger, PD, Turley, P, Visscher, PM, Benjamin, DJ, Cesarini, D
Corporate Authors23andMe Research Team, COGENT (Cognitive Genomics Consortium), Social Science Genetic Association Consortium
JournalNature genetics
Date Published08/2018
Mots-clés80 and over, Adult, Aged, Cohort Studies, Educational Status, Female, Genome-Wide Association Study/methods, Humans, Male, Middle Aged, Multifactorial Inheritance, Phenotype, polymorphism, Single Nucleotide

Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.

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Alternate JournalNat. Genet.
Citation Key / SERVAL ID9006
Peer reviewRefereed
PubMed ID30038396


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