Shared and study-specific dietary patterns and head and neck cancer risk in an international consortium.

TitreShared and study-specific dietary patterns and head and neck cancer risk in an international consortium.
Publication TypeJournal Article
Year of Publication2019
AuthorsDe Vito, R, Lee, YCA, Parpinel, M, Serraino, D, Olshan, AF, Zevallos, JP, Levi, F, Zhang, ZF, Morgenstern, H, Garavello, W, Kelsey, K, McClean, M, Schantz, S, Yu, GP, Boffetta, P, Chuang, SC, Hashibe, M, La Vecchia, C, Parmigiani, G, Edefonti, V
JournalEpidemiology
Volume30
Issue1
Pagination93-102
Date Published01/2019
DOI10.1097/EDE.0000000000000902
ISSN1531-5487
Mots-clés80 and over, Adult, Aged, Case-Control Studies, Confidence Intervals, Diet, Europe/epidemiology, Female, Head and Neck Neoplasms/epidemiology, Humans, Male, Middle Aged, Odds Ratio, Reproducibility of Results, United States/epidemiology
Abstract

BACKGROUND: A few papers have considered reproducibility of a posteriori dietary patterns across populations, as well as pattern associations with head and neck cancer risk when multiple populations are available.

METHODS: We used individual-level pooled data from seven case-control studies (3,844 cases; 6,824 controls) participating in the International Head and Neck Cancer Epidemiology consortium. We simultaneously derived shared and study-specific a posteriori patterns with a novel approach called multi-study factor analysis applied to 23 nutrients. We derived odds ratios (ORs) and 95% confidence intervals (CIs) for cancers of the oral cavity and pharynx combined, and larynx, from logistic regression models.

RESULTS: We identified three shared patterns that were reproducible across studies (75% variance explained): the Anti-oxidant vitamins and fiber (OR=0.57, CI: 0.41-0.78, highest vs. lowest score quintile) and the Fats (OR=0.80, CI: 0.67-0.95) patterns were inversely associated with oral and pharyngeal cancer risk. The Animal products and cereals (OR=1.5, CI: 1.1-2.1) and the Fats (OR=1.8, CI: 1.4-2.3) patterns were positively associated with laryngeal cancer risk, whereas a linear inverse trend in laryngeal cancer risk was evident for the Anti-oxidant vitamins and fiber pattern. We also identified four additional study-specific patterns, one for each of the four US studies examined. We named them all as Dairy products and breakfast cereals and two were associated with oral and pharyngeal cancer risk.

CONCLUSION: Multi-study factor analysis provides insight into pattern reproducibility, and supports previous evidence on cross-country reproducibility of dietary patterns and on their association with head and neck cancer risk.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/30063539?dopt=Abstract

First publication date (online)

07/2018

WOS ID (UT)

000452754000016

Alternate JournalEpidemiology
Citation Key / SERVAL ID9022
Peer reviewRefereed
PubMed ID30063539
Grant ListR03 CA113157 / CA / NCI NIH HHS / United States
R03 DE016611 / DE / NIDCR NIH HHS / United States
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