Colloque "The social regulation of the genome: findings from Add Health"

- Colloque IUMSP
Prof. Michael Shanahan

Jacobs Center for Productive Youth Development
University of Zürich, Zürich

Abstract: The integration of the social sciences and molecular genetics has proceeded at rapid pace, propelled largely by the development of appropriate statistical tools and the collection of DNA in representative datasets. These advances have relied on Genome Wide Association Studies (GWAS), according to which, typically, variation in base pairs (called single nucleotide polymorphisms, or SNPs) predict behavior and social environments.    Recent advances in technology also allow for the collection of gene expression data in population-based studies, data that allow for a new perspective on the interplay between the genome and social forces. In contrast to GWAS, gene expression data indicate how “active” genes are in synthesizing their products.  Second, gene expression data shift the focus from how structural variation in SNPs predict outcomes to how social and physical circumstances turn specific genes more “on” or “off” (upward and downward regulation). The social and physical environment cause changes in gene expression that, in turn, foster physiological adjustments to a person’s surroundings but may also initiate and maintain disease processes. In this talk I report on new data from Add Health (The National Longitudinal Study of Adolescent to Adult Health) that allow us to study how social circumstances are associated with the regulation of gene expression.

Date et heure
Mardi, 30 Octobre, 2018 - 11:00
Salle Delachaux (étage 01), Institut universitaire de médecine sociale et préventive, Bâtiment Biopôle 2, route de la Corniche 10, 1010 Lausanne
Personne de contact: 

Institut universitaire de médecine sociale et préventive
Route de la Corniche 10, 1010 Lausanne - Switzerland
+41 21 314 72 72 |

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