Metabolically Healthy Obesity and High Carotid Intima-Media Thickness in Children and Adolescents: International Childhood Vascular Structure Evaluation Consortium.

TitreMetabolically Healthy Obesity and High Carotid Intima-Media Thickness in Children and Adolescents: International Childhood Vascular Structure Evaluation Consortium.
Publication TypeJournal Article
Year of Publication2019
AuthorsZhao, M, López-Bermejo, A, Caserta, CA, Medeiros, CCampos Mun, Kollias, A, Bassols, J, Romeo, EL, Ramos, TDantas Alm, Stergiou, GS, Yang, L, Xargay-Torrent, S, Amante, A, Gusmão, TMoura Estr, Grammatikos, E, Zhang, Y, Prats-Puig, A, de Carvalho, DFranklin, Yang, L, Carreras-Badosa, G, Simões, Mde Oliveir, Hou, Y, Mas-Pares, B, Shui, W, Guo, T, Wang, M, Chen, H, Lou, X, Zhang, Q, Zhang, Y, Bovet, P, Magnussen, CG, Xi, B
Corporate AuthorsInternational Childhood Vascular Structure Evaluation Consortium
JournalDiabetes Care
Volume42
Issue1
Pagination119-125
Date Published01/2019
DOI10.2337/dc18-1536
ISSN1935-5548
Abstract

OBJECTIVE: It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy of CVD risk, in children and adolescents.

RESEARCH DESIGN AND METHODS: Data were available for 3,497 children and adolescents aged 6-17 years from five population-based cross-sectional studies in Brazil, China, Greece, Italy, and Spain. Weight status categories (normal, overweight, and obese) were defined using BMI cutoffs from the International Obesity Task Force. Metabolic status (defined as "healthy" [no risk factors] or "unhealthy" [one or more risk factors]) was based on four CVD risk factors: elevated blood pressure, elevated triglyceride levels, reduced HDL cholesterol, and elevated fasting glucose. High cIMT was defined as cIMT ≥90th percentile for sex, age, and study population. Logistic regression model was used to examine the association of weight and metabolic status with high cIMT, with adjustment for sex, age, race/ethnicity, and study center.

RESULTS: In comparison with metabolically healthy normal weight, odds ratios (ORs) for high cIMT were 2.29 (95% CI 1.58-3.32) for metabolically healthy overweight and 3.91 (2.46-6.21) for MHO. ORs for high cIMT were 1.44 (1.03-2.02) for unhealthy normal weight, 3.49 (2.51-4.85) for unhealthy overweight, and 6.96 (5.05-9.61) for unhealthy obesity.

CONCLUSIONS: Among children and adolescents, cIMT was higher for both MHO and metabolically healthy overweight compared with metabolically healthy normal weight. Our findings reinforce the need for weight control in children and adolescents irrespective of their metabolic status.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/30420475?dopt=Abstract

First publication date (online)

11/2018

WOS ID (UT)

000453904900027

Alternate JournalDiabetes Care
Citation Key / SERVAL ID9202
Peer reviewRefereed
PubMed ID30420475

                         

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