Social inequalities in sleep-disordered breathing: Evidence from the CoLaus|HypnoLaus study.

TitreSocial inequalities in sleep-disordered breathing: Evidence from the CoLaus|HypnoLaus study.
Publication TypeJournal Article
Year of Publication2018
AuthorsPetrovic, D, Haba-Rubio, J, Carmeli, C, Vollenweider, P, Heinzer, R, Stringhini, S
JournalJournal of sleep research
Paginatione12799
Date Published11/2018
DOI10.1111/jsr.12799
ISSN1365-2869
Mots-clésBMI, mediation, obstructive sleep apnea, oxygen desaturation, Sleep-disordered breathing, Socioeconomic status
Abstract

Sleep-disordered breathing is a common condition, related to a higher cardiometabolic and neurocognitive risk. The main risk factors for sleep-disordered breathing include obesity, craniofacial characteristics, male sex and age. However, some studies have suggested that adverse socioeconomic circumstances and lifestyle-related behaviours such as smoking and alcohol use, may also be risk factors for sleep-disordered breathing. Here, we investigate the associations between socioeconomic status and sleep-disordered breathing, as measured by sleep apnea-hypopnea and oxygen desaturation indexes. Furthermore, we assess whether these associations are explained by lifestyle-related factors (smoking, sedentary behaviour, alcohol use and body mass index [BMI]). We used data from the CoLaus|HypnoLaus study, a population-based study including 2162 participants from Lausanne (Switzerland). Socioeconomic status was measured through occupation and education. Sleep-disordered breathing was assessed through polysomnography and measured using the apnea-hypopnea index (AHI: number of apnea/hypopnea events/hr: ≥15/≥30 events), and the ≥3% oxygen desaturation index (ODI: number of oxygen desaturation events/hr: ≥15/≥30 events). Lower occupation and education were associated with higher AHI and ODI (occupation: AHI30, odds ratio (OR) = 1.88, 95% confidence interval (CI) [1.07; 3.31]; ODI30, OR = 2.29, 95% CI [1.19; 4.39]; education: AHI30, OR = 1.21, 95% CI [0.85; 1.72]; ODI30, OR = 1.26, 95% CI [0.83; 1.91]). BMI was associated with socioeconomic status and AHI/ODI, and contributed to the socioeconomic gradient in SDB, with mediation estimates ranging between 43% and 78%. In this Swiss population-based study, we found that low socioeconomic status is a risk factor for sleep-disordered breathing, and that these associations are partly explained by BMI. These findings provide a better understanding of the mechanisms underlying social differences in sleep-disordered breathing and may help implement policies for identifying high-risk profiles for this disorder.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/30474290?dopt=Abstract

Alternate JournalJ Sleep Res
Citation Key / SERVAL ID9282
Peer reviewRefereed
PubMed ID30474290
Grant List / / Lifepath project /
Horizon 2020 / / European Commission /
633666 / / European Commission /
/ / Swiss State Secretariat for Education, Research and Innovation (SERI) /
3200B0-118308 / / Swiss National Science Foundation /
3200B0-105993 / / Swiss National Science Foundation /
33CS30-139468 / / Swiss National Science Foundation /
33CS30-148401 / / Swiss National Science Foundation /
33CSCO-122661 / / Swiss National Science Foundation /
/ / Medical Research Council /
/ / Portuguese Foundation for Science /
/ / GlaxoSmithKline /
/ / Faculty of Biology and Medicine of the University of Lausanne /
                         

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