Visual Outcomes of Fractionated Radiotherapy in Optic Nerve Sheath Meningioma: A Retrospective Study. [Visuelle Ergebnisse der fraktionierten Strahlentherapie beim Sehnervenscheidenmeningeom: eine retrospektive Studie]

TitreVisual Outcomes of Fractionated Radiotherapy in Optic Nerve Sheath Meningioma: A Retrospective Study. [Visuelle Ergebnisse der fraktionierten Strahlentherapie beim Sehnervenscheidenmeningeom: eine retrospektive Studie]
Publication TypeJournal Article
Year of Publication2019
AuthorsKheir, V, Faouzi, M, Borruat, F-X
JournalKlinische Monatsblatter fur Augenheilkunde
Volume236
Issue4
Pagination526-529
Date Published04/2019
DOI10.1055/a-0828-7335
ISSN1439-3999
Mots-clésoptic nerve sheath meningioma - radiotherapy - visual function
Abstract

BACKGROUND: Optic nerve sheath meningioma (ONSM) is a rare benign tumour of the optic nerve sheath that can lead to blindness if untreated. Radiotherapy is commonly accepted as being the treatment of choice. We conducted a retrospective monocentric study to assess the effect of radiotherapy on visual outcomes and tumour control in patients with ONSM.

PATIENTS AND METHODS: The charts of all patients affected by ONSM between 1994 and 2016 were reviewed retrospectively. Inclusion criteria were: having been followed by our department, initial visual acuity (VA) better than no light perception, and stereotactic fractionated radiotherapy. VA (Snellen), colour vision (Ishihara), and visual field mean defect (in dB), as well as ONSM size (on MRI) were compared before and after radiotherapy. Visual function was considered improved if two or more criteria improved, stabilised if none or only one criterion changed, and worsened if two or more criteria worsened. The Wilcoxon signed-rank test was used to assess the effect of radiotherapy (significant if p value < 0.05).

RESULTS: VA improved or stabilised in 13/16 patients (81.25%), with median VA improving from 0.1 logMAR (8/10) to 0 logMAR (10/10) (p value = 0.0134). Colour vision improved or stabilised in 11/15 patients (73.33%), with median results improving from 5/13 to 12/13 (p value = 0.3212). The visual field mean defect improved in 13/15 patients (86.66%), and the median mean defect (MD) improved from 10 dB to 4 dB (p value = 0.0106). The size of the ONSM diminished or stabilised in 100% of our patients. No adverse events of radiotherapy were either reported or detected.

CONCLUSION: Fractionated radiotherapy is a safe procedure and may improve visual function in patients with ONSM.

Alternate URL

http://www.ncbi.nlm.nih.gov/pubmed/30812038?dopt=Abstract

First publication date (online)

02/2019

WOS ID (UT)

000466183300042

Alternate JournalKlin Monbl Augenheilkd
Citation Key / SERVAL ID9443
Peer reviewRefereed
PubMed ID30812038

                         

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