Differential regulation of RNA polymerase III genes during liver regeneration.

TitreDifferential regulation of RNA polymerase III genes during liver regeneration.
Publication TypeJournal Article
Year of Publication2019
AuthorsYeganeh, M, Praz, V, Carmeli, C, Villeneuve, D, Rib, L, Guex, N, Herr, W, Delorenzi, M, Hernandez, N
Corporate AuthorsCycliX consortium
JournalNucleic Acids Research
Volume47
Issue4
Pagination1786-1796
Date Published02/2019
DOI10.1093/nar/gky1282
ISSN1362-4962
Abstract

Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering the cell division cycle. We have used this system and H3K4me3, Pol II and Pol III profiling to characterize adaptations in Pol III transcription. Our results broadly define a class of genes close to H3K4me3 and Pol II peaks, whose Pol III occupancy is high and stable, and another class, distant from Pol II peaks, whose Pol III occupancy strongly increases after partial hepatectomy. Pol III regulation in the liver thus entails both highly expressed housekeeping genes and genes whose expression can adapt to increased demand.

Alternate URL

https://www.ncbi.nlm.nih.gov/pubmed/30597109?dopt=Abstract

WOS ID (UT)

000467961200019

Alternate JournalNucleic Acids Res.
Citation Key / SERVAL ID9550
Peer reviewRefereed
PubMed ID30597109
PubMed Central IDPMC6393285

                         

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