Effects of short- and long-term exposures to particulate matter on inflammatory marker levels in the general population.

TitreEffects of short- and long-term exposures to particulate matter on inflammatory marker levels in the general population.
Publication TypeJournal Article
Year of Publication2019
AuthorsTsai, D-H, Riediker, M, Berchet, A, Paccaud, F, Waeber, G, Vollenweider, P, Bochud, M
JournalEnvironmental science and pollution research international
Volume26
Issue19
Pagination19697-19704
Date Published07/2019
DOI10.1007/s11356-019-05194-y
ISSN1614-7499
Mots-clésAir Pollution, Inflammation, Long-term, Modeling, Particulate Matter, Short-term
Abstract

The effect of particulate matter (PM) on health increases with exposure duration but the change from short to longer term is not well studied. We examined the exposure to PM smaller 10 μm (PM) from short to longer duration and their associations with levels of inflammatory markers in the population-based CoLaus cohort in Lausanne, Switzerland. Baseline and follow-up CoLaus data were used to study the associations between PM exposure and inflammatory markers, including the high-sensitivity C-reactive protein (CRP), as well as interleukin 1-beta (IL-1β), interleukin 6 (IL-6), and tumor-necrosis-factor alpha (TNF-α) using mixed models. Exposure was determined for each participant's home address from hourly air quality simulations at a 5-m resolution. Short-term exposure intervals were 1 day, 1 week, and 1 month prior to the hospital visit (blood withdrawal); long-term exposure intervals were 3 and 6 months prior to the visit. In most time windows, IL-6, IL-1β, and TNF-α were positively associated with PM. No significant associations were identified for CRP. Adjusted associations with long-term exposures were stronger and more significant than those for short-term exposures. In stratified models, gender, age, smoking status, and hypertension only led to small modifications in effect estimates, though a few of the estimates for IL-6 and TNF-α became non-significant. In this general adult cohort exposed to relatively low average PM levels, clear associations with markers of systemic inflammation were observed. Longer duration of elevated exposure was associated with an exacerbated inflammatory response. This may partially explain the elevated disease risk observed with chronic PM exposure. It also suggests that reducing prolonged episodes of high PM exposure may be a strategy to reduce inflammatory risk.

Alternate URL

https://www.ncbi.nlm.nih.gov/pubmed/31079306?dopt=Abstract

First publication date (online)

05/2019

WOS ID (UT)

000473041000064

Alternate JournalEnviron Sci Pollut Res Int
Citation Key / SERVAL ID9555
Peer reviewRefereed
PubMed ID31079306
Grant List33CSCO-122661 / / Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung /
33CS30-139468 / / Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung /
33CS30-148401 / / Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung /

                         

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