Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease.

TitreMendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease.
Publication TypeJournal Article
Year of Publication2019
AuthorsMarouli, E, M Del Greco, F, Astley, CM, Yang, J, Ahmad, S, Berndt, SI, Caulfield, MJ, Evangelou, E, McKnight, B, Medina-Gomez, C, van Vliet-Ostaptchouk, JV, Warren, HR, Zhu, Z, Hirschhorn, JN, Loos, RJF, Kutalik, Z, Deloukas, P
JournalCommunications biology
Volume2
Pagination119
Date Published2019
DOI10.1038/s42003-019-0361-2
ISSN2399-3642
Abstract

There is evidence that lower height is associated with a higher risk of coronary artery disease (CAD) and increased risk of type 2 diabetes (T2D). It is not clear though whether these associations are causal, direct or mediated by other factors. Here we show that one standard deviation higher genetically determined height (~6.5 cm) is causally associated with a 16% decrease in CAD risk (OR = 0.84, 95% CI 0.80-0.87). This causal association remains after performing sensitivity analyses relaxing pleiotropy assumptions. The causal effect of height on CAD risk is reduced by 1-3% after adjustment for potential mediators (lipids, blood pressure, glycaemic traits, body mass index, socio-economic status). In contrast, our data suggest that lung function (measured by forced expiratory volume [FEV1] and forced vital capacity [FVC]) is a mediator of the effect of height on CAD. We observe no direct causal effect of height on the risk of T2D.

Alternate URL

https://www.ncbi.nlm.nih.gov/pubmed/30937401?dopt=Abstract

WOS ID (UT)

000463365700001

Alternate JournalCommun Biol
Citation Key / SERVAL ID9557
Peer reviewRefereed
PubMed ID30937401
PubMed Central IDPMC6437163
Grant ListK12 DK094721 / DK / NIDDK NIH HHS / United States
R01 DK107786 / DK / NIDDK NIH HHS / United States

                         

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